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. 2022 Feb 10;12:804646. doi: 10.3389/fphys.2021.804646

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Copyright © 2022 Spitz, Erenburg, Kanonenberg, Peherstorfer, Lenders, Reiners, Ma, Luisi, Smits and Schmitt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Helical wheel projections of RTX proteins that can be secreted by the HlyBD-TolC apparatus. Helical wheels were drawn with NetWheel. Non-polar residues are shown in yellow, polar residues in green, basic residues in blue and acidic residues in red. Next to HlyA (A), secretion by HlyBD-TolC has been shown for CyaA (B) by Masure et al. (1990), for FrpA (C) by Thompson and Sparling (1993), for LktA (D) by Highlander et al. (1990), for HlyIA (E) by Gygi et al. (1990) and for PaxA (F) by Kuhnert et al. (2000).