Table 3.
Mode of Action | Target | Name | Type | References |
---|---|---|---|---|
TGF-β ligand inhibitors | TGF-β1, TGF-β2, and TGF-β3 | Fresolimumab | Neutralizing antibody | [318] |
TGF-β1, TGF-β2, and TGF-β3 | SAR439459 | Neutralizing antibody | [320] | |
TGF-β1, TGF-β2, and TGF-β3 | NIS793 | Neutralizing antibody | [320] | |
TGF-β1 and TGF-β3 | AVID200 | Ligand trap | [308] | |
TGF-β1 | Metelimumab | Neutralizing antibody | [324] | |
TGF-β2 | Trabedersen | Antisense oligonucleotide | [308] | |
TGF-β2 | Lucanix | Vaccine | [321] | |
TGF-β1 | LY2382770 | Neutralizing antibody | [325] | |
TGF-β1 | SRK-181 | Neutralizing antibody | [321] | |
TGF-β2 | Lerdelimumab | Monoclonal antibody | [326] | |
TGF-β1 | Disitertide | Peptide | [326] | |
TGF-β1 and TGF-β2 | FANG Vaccine | Vaccine | [326] | |
TGF-β1 | ISTH0036 | Antisense oligonucleotide | [325] | |
TGF-β receptor inhibitors | TGFβRI | Galunisertib | Small molecule inhibitor | [318] |
TGFβRI and TGFβRII | LY2109761 | Small molecule inhibitor | [327] | |
TGFβRI | PF-03446962 | Monoclonal antibody | [318] | |
TGFβRI | IMC-TR1 | Monoclonal antibody | [320] | |
TGFβRI | Vactosertib | Small molecule inhibitor | [318] | |
TGFβRI and TGFβRII | P144 | Ligand trap | [325] |