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. 2022 Feb 10;14(4):883. doi: 10.3390/cancers14040883

Figure 1.

Figure 1

Heatmap of 34 plasma proteins quantified by a multiplex bead-based immunoassay using the baseline plasma of 34 HCC patients treated with Atezo/Bev therapy and 5 healthy controls. The upper heatmap shows each protein level, and the bottom heatmap shows patient backgrounds. IL-5, interleukin-5; CCL4, CC motif chemokine 4; CXCL2, C-X-C motif ligand 2; TNFSF6, tumor necrosis factor superfamily 6; IFN-alpha, interferon-alpha; IL-4, interleukin-4; MICA, MHC class I polypeptide-related sequence A; VEGF-C, vascular endothelial growth factor-C; DKK-1, dickkopf related protein-1; IL-18, interleukin-18; VEGF, vascular endothelial growth factor; CCL2, CC motif chemokine 2; CXCL1: C-X-C motif ligand 1; PD-L1, programmed death-ligand 1; CCL7: CC motif chemokine 7; CCL3, CC motif chemokine 3; IL-2: interleukin-2; IFN-Gamma: interferon-gamma; IL-7, interleukin-7; HGF, hepatocyte growth factor; TSP2, thrombospondin 2; IL-8, interleukin-8; GDF-15, growth/differentiation factor-15; CCL19, CC motif chemokine 19; CX3CL1, C-X3-C motif chemokine ligand 1; IL-6, interleukin-6; IL-12: interleukin-12; IL-1beta, interleukin-1 beta; TNF-alpha, tumor necrosis factor-alpha; CXCL10, C-X-C motif ligand 10; IL-10, interleukin-10; Plt, platelet cell count; AST, aspartate aminotransferase; ALT, alanine aminotransferase; T-Bil, total bilirubin; Alb, albumin; PT, prothrombin time; AFP, alpha fetoprotein; DCP, Des-gamma-carboxy-prothrombin; PD, progressive disease; non-PD, non-progressive disease including complete response, partial response, and stable disease.