Table 4.
Cox proportional hazards analysis of factors related to PFS.
| Univariate Analysis | Multivariate Analysis | ||||||
|---|---|---|---|---|---|---|---|
| Characteristic | Unit | Hazard Ratio | 95% CI | p Value | Hazard Ratio | 95% CI | p Value |
| Age | >72/72 | 0.432 | 0.220–0.849 | 0.015 | 0.306 | 0.140–0.668 | 0.003 |
| Sex | Male/Femal | 1.284 | 0.571–2.887 | 0.545 | |||
| Etiology | Viral/Non-viral | 1.028 | 0.516–2.048 | 0.938 | |||
| Platelets | >12/12 | 1.134 | 0.578–2.230 | 0.712 | |||
| Total Bilirubin | >0.8/0.8 | 1.011 | 0.519–1.968 | 0.975 | |||
| AST | >40/40 | 2.58 | 1.289–5.163 | 0.008 | 1.655 | 0.785–3.488 | 0.186 |
| ALT | >27/27 | 1.77 | 0.894–3.524 | 0.101 | |||
| PT | >90/90 | 1.544 | 0.754–3.167 | 0.235 | |||
| Albumin | >3.6/3.6 | 1.148 | 0.583–2.260 | 0.689 | |||
| Child-Pugh Score | 6,7/5 | 0.76 | 0.386–1.497 | 0.428 | |||
| AFP | >11/11 | 1.953 | 0.998–3.820 | 0.051 | |||
| DCP | >276/276 | 1.478 | 0.742–2.941 | 0.266 | |||
| Distant Metastasis | Present/Absent | 1.349 | 0.693–2.627 | 0.378 | |||
| Vascular Invasion | Present/Absent | 1.924 | 0.792–4.67 | 0.148 | |||
| BCLC Stage | C/A,B | 1.241 | 0.636–2.426 | 0.526 | |||
| Treatment Line | 1st/later | 0.445 | 0.227–0.873 | 0.019 | 0.661 | 0.334–1.310 | 0.236 |
| IL6 | >4.77/4.77 | 2.197 | 1.104–4.372 | 0.025 | 2.785 | 1.216–6.380 | 0.015 |
Abbreviations: AST, aspartate transaminase; ALT, alanine aminotransferase, PT, prothrombin time; AFP, alpha-fetoprotein; DCP, des-γ-carboxy prothrombin; BCLC, Barcelona clinic liver cancer.