Figure 3.

Schematic representation of the conserved motifs of the DEAD-box family of RNA helicase present in GRTH. Nine conserved motifs of GRTH protein were indicated as Q, I, Ia, Ib, II-VI. Amino acid positions of GRTH corresponding to each conserved motif are indicated on top of each motif. Aside from the conserved motifs, GRTH displays low amino acid similarity with other DEAD-box family of RNA helicases. Amino acids within the conserved motifs are specified by their letter code. Among the several serine and threonine residues in the GRTH, only T239 is phosphorylated by PKA (which is highlighted by a red asterisk).