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. 2022 Feb 10;11(4):613. doi: 10.3390/cells11040613

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RNA transport and associated changes occurring in CBs of GRTH-KI mice compared to wild-type mice. GRTH transports essential mRNAs from nucleus to the cytoplasm for translation. The pGRTH, through its interaction with actively elongating polyribosomes, regulates translation of target mRNA. It is involved in transport of mRNPs in and out of the chromatoid body, where it is transiently stored and/or degraded when not needed in the CBs. mRNAs are transported from the CB by pGRTH for translation at specific times during spermatogenesis.