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. 2022 Feb 19;11(4):734. doi: 10.3390/cells11040734

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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H3K4me3 and H3K27me3 localization at the genome-wide level. Genome-wide normalized histone modification signals split into consecutive non-overlapping bins (10 kb) were retrieved from the group-merged BAM file and ranked on the x-axis. Comparison of H3K4me3 (a) and H3K27me3 (b) localization signals between control (blue line) and severe AD group (red line). Severe AD group is characterized by a greater spread in the H3K4me3 signal, while no differences between groups are present in H3K27me3 profiles.