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. 2022 Feb 10;11(4):607. doi: 10.3390/cells11040607

Figure 1.

Figure 1

Selected CVD-associated DOSE terms that are enriched in the validated gene targets of CVD-associated miRNAs. (a) Dot plot of statistically significant, CVD-associated DOSE terms, displaying the gene ratio and statistical significance (p-value < 0.05, following Bonferroni adjustment). (b) Heat map displaying the semantic similarity between the CVD-associated DOSE terms. The DOSE term similarity measurements were performed using the method of Wang et al. [57] and clusterProfiler [55,56]. The DOSE terms were clustered using hierarchical clustering. Clusters with two or more terms are specified with black-colored borders. The heat map was created using ComplexHeatmap [58].