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. 2022 Feb 10;11(4):617. doi: 10.3390/cells11040617

Figure 7.

Figure 7

A model for ABCB4 canalicular membrane expression regulation. In the presence of MRCKα and phosphorylated MRLC, ABCB4 is internalized from the canalicular membrane. In MRCKα knockout cells, MRLC is not phosphorylated, resulting in an accumulation of ABCB4 at the canalicular membrane.