Table 2.
The 40 proteins with significant differences between AAP and mood stabilizer groups. Data are given as fold changes (mean ± s.e.). Cutoff for significance was set at p < 0.01 or if a protein was not detected in one group but detected in one group and present in at least half of samples of the other group. The mean of the normalized PA for each protein in the AAP biopsy samples was set to 1.00, and the fold changes were relative to AAP. ND; not detected. #, only detected in a minimum of 4 out of the 8 AAP muscle samples or 4 out of the 8 MS muscle samples.
| Gene Name | Protein Name | AAP | MS | p-Value |
|---|---|---|---|---|
| ADSSL1 | Adenylosuccinate synthetase isozyme 1 | 1.00 ± 0.07 | 0.61 ± 0.05 | 0.0004 |
| ALDH9A1 | 4-trimethylaminobutyraldehyde dehydrogenase | 1.00 ± 0.18 | 3.54 ± 0.34 | 0.0001 |
| ANXA1 | Annexin A1 | 1.00 ± 0.10 | 0.47 ± 0.09 | 0.0012 |
| ANXA11 | Annexin A11 | 1.00 ± 0.15 | 0.33 ± 0.15 | 0.0073 |
| ANXA5 | Annexin A5 | 1.00 ± 0.10 | 0.62 ± 0.08 | 0.0091 |
| ATP5D | ATP synthase subunit delta, mitochondrial | 1.00 ± 0.10 | 2.02 ± 0.30 | 0.0098 |
| BTBD10 | BTB/POZ domain-containing protein 10 | 1.00 ± 0.24 | 1.87 ± 0.06 | 0.0084 |
| C1QBP | Complement component 1 Q subcomponent-binding protein, mitochondrial | 1.00 ± 0.14 | 0.50 ± 0.06 | 0.0038 |
| CAPNS1 | Calpain small subunit 1 | 1.00 ± 0.13 | 1.64 ± 0.15 | 0.0042 |
| CKAP4 | Cytoskeleton-associated protein 4 | ND | 1.00 ± 0.15 | <0.01 # |
| COL6A1 | Collagen alpha-1(VI) chain | ND | 1.00 ± 0.25 | <0.01 # |
| COL6A3 | Collagen alpha-3(VI) chain | 1.00 ± 0.25 | ND | <0.01 # |
| DDX1 | ATP-dependent RNA helicase DDX1 | 1.00 ± 0.09 | 0.57 ± 0.06 | 0.0032 |
| ECHS1 | Enoyl-CoA hydratase, mitochondrial | 1.00 ± 0.23 | 0.36 ± 0.05 | 0.0009 |
| EEF2 | Elongation factor 2 | 1.00 ± 0.11 | 0.63 ± 0.06 | 0.0088 |
| FABP3 | Fatty acid-binding protein | 1.00 ± 0.14 | 1.71 ± 0.23 | 0.0088 |
| FERMT2 | Fermitin family homolog 2 | 1.00 ± 0.16 | ND | <0.01 # |
| FHL1 | Four and a half LIM domains protein 1 | 1.00 ± 0.08 | 1.66 ± 0.14 | 0.0012 |
| GDI1 | Rab GDP dissociation inhibitor alpha | 1.00 ± 0.05 | 0.42 ± 0.03 | 0.0017 |
| HNRNPDL | Heterogeneous nuclear ribonucleoprotein D-like | ND | 1.00 ± 0.24 | <0.01 # |
| HSPA6/7 | Heat shock 70 kDa protein 6/7 | 1.00 ± 0.08 | 1.66 ± 0.18 | 0.0034 |
| KPNB1 | Importin subunit beta-1 | 1.00 ± 0.17 | 0.46 ± 0.06 | 0.0052 |
| LMNA | Lamin-A/C | 1.00 ± 0.07 | 1.88 ± 0.27 | 0.0077 |
| MTHFD1 | Methylenetetrahydrofolate dehydrogenase | 1.00 ± 0.13 | 0.32 ± 0.04 | 0.0003 |
| MYH3 | Myosin-3 | 1.00 ± 0.31 | 5.41 ± 1.07 | 0.0017 |
| NME1/2 | Nucleoside diphosphate kinase A/B | 1.00 ± 0.21 | 2.81 ± 0.52 | 0.0035 |
| PARK7 | Protein deglycase DJ-1 | 1.00 ± 0.08 | 0.61 ± 0.09 | 0.0045 |
| PDIA6 | Protein disulfide-isomerase A6 | 1.00 ± 0.10 | 0.53 ± 0.08 | 0.0050 |
| PLCL1 | Phosphoinositide phospholipase C | 1.00 ± 0.08 | 1.59 ± 0.20 | 0.0074 |
| PLIN4 | Perilipin-4 | 1.00 ± 0.10 | 2.50 ± 0.46 | 0.0016 |
| PRDX1 | Peroxiredoxin-1 | 1.00 ± 0.13 | 1.57 ± 0.14 | 0.0099 |
| PRDX2 | Peroxiredoxin-2 | 1.00 ± 0.09 | 1.59 ± 0.12 | 0.0020 |
| RPL13 | 60S ribosomal protein L13 | ND | 1.00 ± 0.13 | <0.01 # |
| RPN2 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 | 1.00 ± 0.27 | 0.10 ± 0.02 | 0.0075 |
| RPSA | 40S ribosomal protein SA | 1.00 ± 0.09 | 0.49 ± 0.04 | 0.0001 |
| SRL | Sarcalumenin | 1.00 ± 0.09 | 0.60 ± 0.05 | 0.0025 |
| YWHAG | 14-3-3 protein gamma | 1.00 ± 0.15 | 0.46 ± 0.09 | 0.0058 |
| YWHAH | 14-3-3 protein eta | 1.00 ± 0.15 | 0.43 ± 0.07 | 0.0031 |
| YWHAQ | 14-3-3 protein theta | 1.00 ± 0.18 | 0.41 ± 0.04 | 0.0044 |
| YWHAZ | 14-3-3 protein zeta/delta | 1.00 ± 0.19 | 0.40 ± 0.08 | 0.0030 |