Table 3.
Enriched pathways based on the 40 proteins with a significant difference between AAP and mood stabilizers using Ingenuity Pathway Analysis.
| Ingenuity Canonical Pathways | FDR q-Value |
Proteins Assigned to a Pathway |
|---|---|---|
| p70S6K Signaling | 0.000028 | YWHAQ, YWHAG, YWHAH, EEF2, YWHAZ, PLCL1 |
| Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 0.0001 | YWHAQ, YWHAG, YWHAH, YWHAZ |
| 14-3-3-mediated Signaling | 0.0002 | YWHAQ, YWHAG, YWHAH, YWHAZ, PLCL1 |
| ERK5 Signaling | 0.0003 | YWHAQ, YWHAG, YWHAH, YWHAZ |
| Myc Mediated Apoptosis Signaling | 0.0003 | YWHAQ, YWHAG, YWHAH, YWHAZ |
| HIPPO signaling | 0.0003 | YWHAQ, YWHAG, YWHAH, YWHAZ |
| IGF-1 Signaling | 0.001 | YWHAQ, YWHAG, YWHAH, YWHAZ |
| PI3K/AKT Signaling | 0.001 | YWHAQ, YWHAG, YWHAH, YWHAZ |
| ERK/MAPK Signaling | 0.007 | YWHAQ, YWHAG, YWHAH, YWHAZ |
| Protein Kinase A Signaling | 0.008 | YWHAQ, YWHAG, YWHAH, YWHAZ, PLCL1 |
| L-carnitine Biosynthesis | 0.05 | ALDH9A1 |
| Diphthamide Biosynthesis | 0.05 | EEF2 |
| Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate | 0.07 | MTHFD1 |
| Folate Polyglutamylation | 0.07 | MTHFD1 |
| Apoptosis Signaling | 0.1 | CAPNS1, LMNA |
| Histidine Degradation III | 0.1 | MTHFD1 |
| Folate Transformations I | 0.1 | MTHFD1 |
| Calcium Transport I | 0.1 | ANXA5 |
| Purine Nucleotides De Novo Biosynthesis II | 0.1 | ADSSL1 |