Table 6.
The table shows the factors associated with a new diagnosis of deep vein thrombosis (DVT), pulmonary embolism (PE), or venous thromboembolism (VTE) after breast surgery. In addition, the table shows the sub-cohort of invasive breast cancer analysis. The reported values refer to multivariate Cox proportional hazards model analysis considering the new diagnosis of DVT, PE, or VTE after breast surgery.
| Variables | DVT | PE | VTE | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| Invasive breast cancer sub-cohort (†) | ||||||
| Woman’s age (years) | 1.04 (1.01–1.07) | <0.05 | ||||
| BMI (kg/m²) | 1.06 (1.01–1.12) | <0.05 | 1.10 (1.03–1.17) (¶) | <0.05 | 1.06 (1.00–1.12) (¶) | 0.054 |
| Chronic hypertension | 1.98 (1.07–3.63) | <0.05 | 2.99 (1.31–6.85) (¶) | <0.05 | 2.35 (1.3–4.24) (¶) | <0.05 |
| Chronic lung disease | 2.93 (0.87–9.90) (§) | 0.084 | ||||
| Other type of invasive carcinoma | 3.5 (1.18–10.39) (§) | <0.05 | 1.93 (0.69–5.4) (§) | 0.211 | ||
| TNM stage (III–IV) | 1.91 (1–3.65) | 0.050 | 3.63 (2.01–6.55) (§) | <0.05 | ||
| Comedo-like necrosis | 5.24 (2.08–13.19) (§) | <0.05 | 0.69 (0.17–2.86) (§) | 0.612 | ||
| Molecular subtype (basal-like) | 2.46 (1.19–5.08) | <0.05 | 3.56 (1.76–7.18) (§) | <0.05 | ||
| Matted axilla lymph nodes | 7.4 (2.53–21.69) (§) | <0.05 | ||||
| Locoregional recurrence | 0.44 (0.13–1.51) | 0.193 | 2.89 (0.99–8.42) (§) | 0.052 | ||
| Distant metastases diagnosed during follow-up | 4.42 (2.17–8.99) | <0.05 | 7.04 (3.8–13.04) (§) | <0.05 | ||
| Adjuvant radiotherapy | 1.74 (0.92–3.26) | 0.086 | ||||
| Adjuvant chemotherapy | 2.11 (1.02–4.37) | <0.05 | ||||
The initial multivariate model considered the following factors: (†) Woman’s age, BMI, post-menopausal status, chronic hypertension, chronic lung disease, breast lesion histology, adjuvant chemotherapy, tumor size, nodal status, tumor grading, tumor stage, comedo-like necrosis, tumor molecular subtype, lymph node extracapsular invasion, matted axilla lymph nodes, adjuvant radiotherapy, adjuvant chemotherapy, locoregional recurrences, and distant metastasis recurrences. (§) Multivariate model with adjustment for BMI and chronic hypertension. (¶) Model including BMI and chronic hypertension. Other acronyms: BMI = body mass index; CI = confidence interval; HR = hazard ratio; TNM = tumor, nodes, and metastases.