Table 1.
Demographic characteristics of the study group and comparison between the group treated with IVIG and the group treated with IVIG+GCS.
| IVIG n = 76 | IVIG+GCS n = 91 | p | |
|---|---|---|---|
| Sex m/f (%m) | 46/30 (61%) | 65/26 (71%) | 0.14 |
| Age, years | 8.7 (4.6–11.3) | 9.4 (5.2–12.5) | 0.15 |
| Body mass index z-score | −0.03 (−0.79–0.70) | 0.41 (−0.65–1.16) | 0.06 |
| Obesity | 3% | 7% | 0.27 |
| Fever before hospitalization, days | 4 (3–6) | 4 (2–4) | 0.17 |
| Skin rash, (%) | 81% | 89% | 0.18 |
| Conjunctivitis, (%) | 79% | 86% | 0.27 |
| Oral inflammation, (%) | 62% | 68% | 0.42 |
| Erythema of hands or feet, (%) | 51% | 60% | 0.28 |
| Gastrointestinal symptoms, (%) | 92% | 96% | 0.33 |
| Echocardiographic abnormalities, (%) | 22% | 50% | <0.001 |
| CXR or CT abnormalities, (%) | 16% | 29% | 0.06 |
| Reduced left ventricle contractility on admission, % | 9/70, 13% | 30/84, 36% | 0.001 |
| Coronary artery dilatation on admission, % | 3/70, 4% | 9/84, 11% | 0.14 |
| Pericardial effusion on admission, % | 5/70, 7% | 6/84, 7% | 1.0 |
| Treated at PICU, (%) | 1% | 10% | 0.02 |
| Oxygen supplementation, n (%) | 12% | 28% | 0.02 |
| Complete recovery at discharge | 98% | 92% | 0.09 |
| CRP, mg/L | 140.9 (88.4–187) | 132.1 (69–185.2) | 0.5 |
| Lactate, mmoL/L | 1.9 (1.2–2.4) | 2.5 (1.8–3.2) | 0.05 |
| Hb on admission, g/dL | 11.5 (10.3–12.7) | 12.0 (11.1–13.4) | 0.03 |
| Anaemia on admission, % | 48% | 33% | 0.056 |
| WBC, ×103/µL | 10.6 (7.3–14) | 8.3 (6.2–12.3) | 0.03 |
| Neutrophils, ×103/µL | 8 (5.7–11) | 7 (4.7–10.5) | 0.28 |
| Lymphocytes, ×103/µL | 1.5 (1–2) | 0.9 (0.6–1.4) | <0.001 |
| PLT, ×103/µL | 196.5 (148–304) | 159.5 (112–227) | 0.002 |
| D-dimers, mg/L | 2.2 (1.4–3) | 3.4 (1.5–5.6) | 0.007 |
| INR | 1.2 (1.1–1.3) | 1.3 (1.2–1.4) | 0.001 |
| APTT, s | 34 (31.5–38.6) | 36.9 (34.3–40.5) | 0.03 |
| ALT, U/L | 19.5 (13–29.5) | 27 (17–48) | <0.001 |
| Bilirubin, mg/dL | 0.4 (0.3–0.6) | 0.6 (0.4–1.1) | 0.05 |
| Sodium, mmoL/L | 135 (133–138) | 134 (131–136) | 0.007 |
| NT pro-BNP, pg/mL | 1581 (718–5791) | 3966 (793–11416) | 0.14 |
| Creatinine, mg/dL | 0.4 (0.3–0.6) | 0.6 (0.4–0.7) | 0.003 |
| CK, U/L | 40 (19–58) | 59.5 (39–126) | 0.008 |
ALT—alanine aminotransferase, BMI—body mass index, CRP—C-reactive protein, CK—creatinine kinase, CT—computed tomography, CXR—chest X-ray, GCS—glucocorticoids, INR—international normalized ration, IVIG—intravenous immunoglobulins, NT-pro-BNP—N-terminal pro b-type natriuretic peptide, PICU—pediatric intensive care unit, PLT—platelets, WBC—white blood cells.