Table 2. Maternal and gestational age at delivery as well as sFlt-1/PlGF ratio at baseline visit in women with and without PE from the RWD, RWD prediction only and PROGNOSIS cohorts.
| Parameter | Cohort | Group | N | Mean | SD | Median | IQR | Min. | Max. | p-value |
|---|---|---|---|---|---|---|---|---|---|---|
| Maternal age at delivery (years) | RWD | All | 281 | 30.4 | 5.6 | 30.0 | 7.0 | 18.0 | 45.0 | 0.6908 |
| No PE | 239 | 30.3 | 5.7 | 30.0 | 7.0 | 18.0 | 45.0 | 0.7634 | ||
| PE | 42 | 30.6 | 5.4 | 30.0 | 6.0 | 18.0 | 44.0 | 0.7869 | ||
| RWD prediction only | All | 99 | 30.8 | 5.2 | 30.0 | 6.0 | 18.0 | 44.0 | 0.3902 | |
| No PE | 93 | 30.6 | 5.1 | 29.0 | 6.0 | 18.0 | 44.0 | 0.6077 | ||
| PE | 6 | 34.2 | 5.2 | 32.0 | 8.0 | 27.0 | 40.0 | 0.1529 | ||
| PROGNOSIS | All | 203 | 30.1 | 5.6 | 30.0 | 8.0 | 18.0 | 43.0 | reference | |
| No PE | 175 | 30.1 | 5.7 | 30.0 | 8.0 | 18.0 | 43.0 | reference | ||
| PE | 28 | 30.3 | 5.4 | 30.0 | 8.0 | 20.0 | 42.0 | reference | ||
| Gestational age at delivery (weeks) | RWD | All | 281 | 36.8 | 4.2 | 38.1 | 3.0 | 23.0 | 41.1 | 0.0052 |
| No PE | 239 | 37.5 | 3.7 | 39.0 | 3.0 | 23.0 | 41.1 | 0.0021 | ||
| PE | 42 | 32.9 | 5.0 | 34.0 | 8.0 | 23.0 | 40.1 | 0.5895 | ||
| RWD prediction only | All | 99 | 37.9 | 3.3 | 39.0 | 2.0 | 25.1 | 41.1 | <0.0001 | |
| No PE | 93 | 38.6 | 2.2 | 39.0 | 2.0 | 28.1 | 41.1 | <0.0001 | ||
| PE | 6 | 28.2 | 3.4 | 27.1 | 4.0 | 25.1 | 34.1 | 0.0038 | ||
| PROGNOSIS | All | 203 | 36.3 | 3.8 | 37.4 | 4.0 | 24.3 | 41.9 | reference | |
| No PE | 175 | 36.8 | 3.7 | 38.0 | 3.0 | 24.3 | 41.9 | reference | ||
| PE | 28 | 33.6 | 3.3 | 34.3 | 5.0 | 26.3 | 39.1 | reference | ||
| sFlt-1/PlGF ratio at baseline visit | RWD | All | 281 | 95.8 | 220.9 | 22.4 | 76.2 | 0.5 | 2430.7 | 0.0996 |
| No PE | 239 | 60.9 | 181.9 | 17.6 | 47.1 | 0.5 | 2430.7 | 0.2246 | ||
| PE | 42 | 294.4 | 306.1 | 151.9 | 402.4 | 4.5 | 1065.3 | 0.0582 | ||
| RWD prediction only | All | 99 | 47.2 | 137.7 | 8.0 | 19.4 | 0.5 | 974.5 | 0.0173 | |
| No PE | 93 | 23.8 | 60.0 | 6.3 | 18.5 | 0.5 | 509.7 | 0.0469 | ||
| PE | 6 | 409.2 | 371.6 | 317.7 | 428.0 | 18.7 | 974.5 | 0.1614 | ||
| PROGNOSIS | All | 203 | 76.4 | 199.9 | 13.2 | 69.7 | 0.6 | 1831.1 | reference | |
| No PE | 175 | 60.5 | 172.7 | 10.2 | 45.7 | 0.6 | 1831.1 | reference | ||
| PE | 28 | 176.2 | 307.8 | 117.2 | 120.5 | 1.5 | 1615.4 | reference |
IQR, interquartile range; Max., maximum; Min., minimum; N, total number of women in cohort; PE, preeclampsia; PlGF, placental growth factor; RWD, real-world data; SD, standard deviation; sFlt-1, soluble fms-like tyrosine kinase 1.