Table 1. Demographics of fetuses with Dandy-Walker malformation.
| Participant | Volumetric analysis | Maternal age | Fetal sex | Chromosomal abnormalities | GA of MRI [weeks] | Associated cerebral anomalies | Extracerebral anomalies | Number of vermian lobules |
|---|---|---|---|---|---|---|---|---|
| BCH_CM01 | Y | 24 | M | Negative | 19.29 | Hydrocephalus | Cystic kidneys | N/A |
| BCH_CM02 | Y | 19 | F | Negative | 23.43 | None | None | 3.67 |
| BCH_CM03 | Ya | 37 | F | 46,XX,add(6)(p25) | 23.29 | Hydrocephalus partial ACC |
Hypertelorism CoA |
1.00 |
| BCH_CM05 | Y | 38 | F | Negative | 19.00 | None | None | N/A |
| BCH_CM06 | Y | 30 | F | Negative | 24.14 | Hydrocephalus | None | 4.00 |
| BCH_CM07 | Y | 24 | M | Negative | 19.86 | Ventriculomegaly | None | N/A |
| BCH_CM08 | Y | 31 | M | Negative | 22.14 | None | TOF | 1.00 |
| BCH_CM09 | Ya | 20 | F | 46,XX,del(3)(q21q25) | 33.14 | Ventriculomegaly partial ACC | CDH VSD hypoplastic LV Hydronephrosis FGR |
1.00 |
| BCH_CM10 | Y | 23 | M | absence of heterozygosity in 6q and 14q | 28.00 | Ventriculomegaly | Craniofacial disproportion Hydronephrosis |
3.67 |
| BM69 | Ya | 42 | M* | N/A | 20.14 | ACC | AVCD PA |
N/A |
| BM83 | Y | 37 | M | Negative | 19.14 | None | None | N/A |
| BM84 | Ya | 32 | M | 47,XY,+9 | 22.57 | ACC | Skeletal anomalies DORV FGR |
1.33 |
| BCH_CM04 | N | 33 | M | Negative | 20.00 | None | None | N/A |
| BCH_CM11 | N | 23 | N/A | N/A | 27.71 | Encephalocele ACC | None | N/A |
| BCH_CM12 | N | 39 | Unknown | Negative | 19.29 | Schizencephaly Nodular heterotopia | None | N/A |
Three participants (rows highlighted in grey) were excluded from volumetric analysis and assessment of vermian lobulation due to associated central nervous system anomalies or poor imaging quality. The maximum number of differentiable vermian lobules was defined as seven. The number of vermian lobules represents the mean value among the three raters.
Y, eligible for volumetrics; Ya, eligible for volumetrics but excluded from the subgroup analysis due to callosal anomalies; N, ineligible for volumetric analysis; M*, male external genitalia on fetal MRI; ACC, agenesis of the corpus callosum; AVCD, atrioventricular canal defect; CoA, coarctation of the aorta; CDH, congenital diaphragmatic hernia; DORV, double outlet right ventricle; FGR, fetal growth restriction; GA, gestational age; LV, left ventricle; PA, pulmonary atresia; TOF, tetralogy of Fallot; VSD, ventricular septal defect.