Table 1.

Univariate and multivariate Cox regression analysis of factors associated with overall survival and disease-free survival.

	OS						DFS
	Univariate			Multivariate			Univariate			Multivariate
Factor	HR	95% CI	p Value	HR	95% CI	p Value	HR	95% CI	p Value	HR	95% CI	p Value
Sex (male)	1.265	0.254–6.300	0.774				1.693	0.496–5.786	0.401
Age (years)	1.008	0.941–1.080	0.815				1.028	0.981–1.076	0.249
Liver cirrhosis (yes vs. no)	3.747	0.450–31.170	0.222				0.747	0.280–1.994	0.560
Platelet (109/L)	1.002	0.993–1.011	0.627				1.007	1.001–1.012	0.015	1.015	1.005 – 1.024	0.002
Albumin (g/dL)	0.685	0.323–1.451	0.323				0.713	0.464–1.096	0.123
Total bilirubin (mg/dL)	1.502	1.083–2.083	0.015				1.380	0.993–1.917	0.055
Creatinine (mg/dL)	0.005	0.000–0.838	0.043				0.187	0.013–2.608	0.212
Serum AST (U/L)	1.002	0.996–1.007	0.588				1.001	0.996–1.006	0.790
Serum ALT (U/L)	1.007	1.000–1.013	0.035				1.005	1.000–1.010	0.057
Serum AFP (ng/mL)	1.000	1.000–1.000	<0.001	1.000	1.000 – 1.000	0.003	1.000	1.000–1.000	0.003
PIVKA II (mAU/mL)	1.000	1.000–1.000	0.003				1.000	1.000–1.000	0.002
MVI (yes vs no)	0.002	0.000–7.853	0.144				13.464	4.210–43.055	<0.001	18.674	4.103 – 84.996	<0.001
mUICC (III-IV vs. I-II)	17.153	2.092–140.608	0.008				7.691	2.889–20.473	<0.001
Tumor grade (3–4 vs. 1–2)	0.045	0.000–32,060.773	0.653				22.504	0.004–144,372.189	0.486
SNRPB	5.672	1.051–30.609	0.044				4.550	1.496–13.836	0.008
CETN2	4.742	1.280–17.572	0.020				3.259	1.361–7.801	0.008
HMGA1	4.065	1.244–13.288	0.020				3.166	1.562–6.415	0.001	2.905	1.148 – 7.353	0.024
MPZL1	1.435	0.506–4.073	0.497				1.300	0.654–2.584	0.453
RACGAP1	6.631	2.375–18.519	<0.001	34.162	3.486 – 334.737	0.002	5.212	2.386–11.383	<0.001