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. 2022 Feb 14;11(4):660. doi: 10.3390/cells11040660

Figure 3.

Figure 3

Treatment with PF-04957325 suppresses leukocyte infiltration into the spinal cord. Mice with EAE scores of at least 1 were treated with the vehicle control or PF-04957325 three times daily, for 6 to 13 days. The data represent the total number of mononuclear cells in the spinal cord (CNS) after Percoll gradient isolation (A) (n =10 mice per group, five independent experiments; * p = 0.015)), in cervical lymph nodes (CELN) (B), and spleens (C) (n = 9 mice per group, mean ± SEM of four independent experiments) counted by trypan blue exclusion assay. The horizontal lines indicate comparisons between each pair of vehicle control- or PF-04957325-treated mice enrolled in the treatment regimen at the same time.