Table 1.

Main ROS-1-fusion partners in ROS-1-positive non-small-cell lung cancers.

Gene	Description	Frequency	Reference
CD74	Cluster of differentiation 74 (several subtypes: C6R34, C6R32 C7R32, C3R34)	38–54%	[11]
EZR	Ezrin	13–24%	[37]
SDC4	Syndecan 4	9–13%	[37]
SLC34A2	Solute carrier family-34 member-2 gene	5–10%	[11]
TPM3	Tropomyosin-3 gene	3–15%	[14]
FIG or GOPC	Fused in glioblastoma (associated with cancers other than NSCLC) or golgi-associated PDZ and coiled-coil motif-containing	2–3%	[38]
ADGRG6	Adhesion G protein-coupled receptor G6	1%	[39]
ANKS1B	Ankyrin repeat and sterile alpha motif domain containing 1B	1%	[40]
CCDC6 or CCKC6	Coiled-coil domain containing 6	1%	[34,41]
CEP72	Centrosomic protein 72	1%	[42]
CLTC	Clathrin heavy chain	1%	[43]
FAM135B	Family with sequence similarity 135 member B	1%	[44]
FBXF17	F-box and leucine-rich repeat protein 17	1%	[44]
FRK	Src family tyrosine kinase	1%	[40]
KDELR2, ELP-1 or ERD2.2	Endoplasmic reticulum protein retention receptor 2	1%	[34]
SKT	Human homologue of murine Skt (Sickle tail)	1%	[41]
LIMA (or EPLIN)	LIM (Lotus-Intel-Microsoft) domain and actin-binding 1	1%	[2]
LRIG3	Leucine-rich repeats and immunoglobulin-like domain 3	1%	[14]
MLL3	Mixed lineage leukemia	1%	[12]
MPRIP	Myosin phosphatase Rho-interacting protein	1%	[45]
MSN	Moesin	1%	[2]
MYH9	Myosin, heavy polypeptide 9, non-muscle	1%	[34,46]
MYOC 5	Myosin-gene family myosin VC	1%	[23]
RBPMS	RNA-binding protein with multiple splicing	1%	[47]
SLC2A4RG	solute carrier family-2 member-4	1%	[34]
SLC6A17	Solute carrier family-6 member-17	1%	[42]
SLMAP	Sarcolemma-associated protein	1%	[23]
SNN	Stannin	1%	[41]
SQSTM1	Sequestosome 1	1%	[40]
TDP52L1	Tumor protein D52-like 1	1%	[42]
TMEM106B	Transmembrane protein 106B	1%	[8]
TRG or TFG	TRK (transketolase-related gene)-fused gene	1%	[41]
WNK1	Lysine deficient protein kinase 1	1%	[34,41]
ZZCCHC8 or ZCCH	Zinc finger CCHC-type containing 8	1%	[41]