Table 4.

Summary of cohort studies relating to neoplasia (abbreviations: ([¹⁸F]FDG, 2-deoxy-2-[¹⁸F]fluoro-D-glucose; [¹¹¹In]In OCT, Indium pentetreotide; Pt, number of patients).

Author	Ref	Type of Study	Pt	Radiotracer Scanner, Injected Activity and Delay before Acquisition	Comments
Phosphaturic mesenchymal tumors (PMT)
John, J. (2019)	[38]	Retrospective	16	[68Ga]Ga-DOTA-TATE PET/CT(Siemens Biograph) 75–185 MBq, 30–45 min	Out of 16 patients with clinically suspected oncogenic osteomalacia 13 patients were found to be SSTR PET positive for a possible mesenchymal tumour. 10 patients underwent surgery, all of which biopsy confirmed PMT.
Paquet, M. (2018)	[40]	Prospective	15	[68Ga]Ga-DOTA-TOC PET/CT(Siemens Biograph mCT, Phillips GeminiTF16), 1.6 MBq/kg, 60 min.	9/15 identified suspect tumor, 8 removed surgically, all of them histologically proven to be PMT.
Singh, D. (2017)	[49]	Prospective	17	[68Ga]Ga-DOTA-NOC PET/CT (Siemens mCT biograph 64), 111–148 MBq, 45 ± 15 min.	DOTANOC PET/CT revealed 52 lesions in 17 patients with elevated FGF-23 and hypophosphatemia, where 11 were highly suspicious for culprit lesions. Subsequent anatomical imaging with CT/MRI showed concordant results in 7 out of 9 patients. These lesions were excised and histologically verified PMTs. Multiple lesions make it difficult to identify the culprit lesion.
Satyaraddi, A. (2017)	[41]	Retrospective	13	[68Ga]Ga-DOTA-TATE, [18F]FDG Scan details not given	DOTATATE revealed PMT in 9/9 patients, of whom 3 declined surgery. Other 6 had histologically verified PMTs.
González, G. (2017)	[42]	Retrospective	6	[68Ga]Ga-DOTA-TATE Scan details not given	Two tumors located using DOTATATE
El-Maouche, D. (2016)	[43]	Prospective	11	[68Ga]Ga-DOTA-TATE PET/CT(Siemens mCT), ca 185 MBq, 60 min [111In]In-OCT, [18F]FDG	6/11 patients had tumor successfully identified. DOTATATE identified 6/6, [111In]In-OCT and [18F]FDG both with 4/6.
Bhavani, N. (2016)	[44]	Retrospective	10	[68Ga]Ga-DOTA-NOC PET/CT (GE Discovery 609) 111–185 MBq, 60 min	DOTANOC detected PMT in 9/10 cases. 6/10 made full clinical recovery after complete resection.
Zhang, J. (2015)	[45]	Retrospective	54	[68Ga]Ga-DOTA-TATE PET/CT(Siemens Biograph 64) 111–148 MBq, ca 45 min	DOTATATE positive in 44 patients, where 33 had surgery to remove lesions. 32 histologically confirmed PMT. 10 who were not positive responded well to conservative treatment and thus PMT can be ruled out.
Agrawal, K. (2015)	[46]	Retrospective	6	[68Ga]Ga-DOTA-TATE PET/CT(GE Discovery STE-16) 1.5 MBq/kg, 45–60 min, [18F]FDG	[18F]FDG-PET identified PMT in 2/4 patients. DOTATATE identified PMT in 5/6 patients.
Jadhav, S. (2014)	[47]	Retrospective	16	[68Ga]Ga-DOTA-TATE PET/CT (Discovery STE) 74–111 MBq, 60–90 min. [18F]FDG, [99Tc]Tc-HYNIC-TOC	9/16 patients had tumor successfully identified. DOTATATE, HYNIC-TOC (tectrotyd) both identified 7/7, [18F]FDG 4/8.
Breer, S. (2014)	[14]	Prospective	5	[68Ga]Ga-DOTA-TATE PET/CT(Siemens Biograph), 58–110 MBq, 20 min, [111In]In-OCT	[111In]In-OCT SPECT-CT identified 1/5 tumors, DOTATATE-PET 5/5. Histologically confirmed PMT.
Clifton-Bligh, R. (2013)	[48]	Prospective	6	[68Ga]Ga-DOTA-TATE PET/CT, 103–226 MBq, 45–60 min	DOTATATE detected PMT in all 6 cases. 5/6 made full clinical recovery after resection. Patient with symptoms with residual on follow up PET.
Juvenile angiofibroma
Gronkiewicz, Z. (2016)	[67]	Prospective	6	[68Ga]Ga-DOTA-TATE PET/CT (Siemens Biograph 64) 120–160 MBq, 60 min	DOTATATE showed uptake in areas matching the pathologic tissue in juvenile angiofibroma.
Multiple myeloma
Sonmezoglu, K. (2017)	[71]	Prospective	21	[68Ga]Ga-DOTA-TATE PET/CT (Siemens Biograph 6 or GE Discovery V710), 100–150 MBq, 45–60 min. [18F]FDG	No significant difference was found between the two modalities in terms of lesion numbers detected in multiple myoma. However, diffuse bone marrow uptake of DOTATATE seems to be a predicting factor for overall survival.