Table 5.
Multivariate analysis by Cox proportional hazards regression analysis for biomarkers associated with time-to-MV.
| A. Analysis of biomarkers at admission | |||
| RR | 95%CI | p Value | |
| CRP (mg/dL) | 33.1 | 3.2–372.6 | 0.0028 * |
| Interleukin-6 (pg/mL) | 14.5 | 0.67–142.7 | 0.041 * |
| KL-6 (IU/mL) | 64.7 | 3.6–804.4 | 0.0013 * |
| B. Analysis of biomarkers at 3 days after admission | |||
| RR | 95%CI | p Value | |
| Platelet (×104/µL) | −0.37 § | −0.72–−0.14 § | 0.00060 * |
| CRP (mg/dL) | −0.33 § | −0.96–−0.044 § | 0.021 * |
| HMGB-1 (ng/mL) | 0.22 § | 0.054–0.46 § | 0.011 * |
| d-dimer (µg/mL) | 0.93 § | 0.083–2.1 § | 0.00037 * |
§ parameter estimates; CRP, C-reactive protein; KL-6, Krebs von den Lungen-6; HMGB-1, high-mobility group box-1 protein; RR, relative risk; 95% CI, 95% confidence interval. * A value of p < 0.05 was considered to represent statistical significance.