Table 7.
Summary of pathological changes in rats fed with commercial non-GM, GM-1, and GM-2 soybeans for 90 days.
| Organ | Histopathological Findings | Group (5 g/kg) | |||||
|---|---|---|---|---|---|---|---|
| Male | Female | ||||||
| Non- GM |
GM -1 |
GM -2 |
Non -GM |
GM -1 |
GM -2 |
||
| Adrenal gland | - | - | - | - | - | - | |
| Aorta | - | - | - | - | - | - | |
| Brain | |||||||
| Fore | - | - | - | - | - | - | |
| Middle | - | - | - | - | - | - | |
| Cerebellum | - | - | - | - | - | - | |
| Stem | - | - | - | - | - | - | |
| Bone, femur | - | - | - | - | - | - | |
| Bone marrow | |||||||
| Femur and sternum | - | - | - | - | - | - | |
| Cervix | N | N | N | - | - | - | |
| Epididymis | - | - | - | - | - | - | |
| Esophagus | - | - | - | - | - | - | |
| Eyes | - | - | - | - | - | - | |
| Harderian gland | |||||||
| Infiltration, mononuclear cell, focal, minimal to slight a | - | - | 1/9 b | 1/10 | - | - | |
| Heart | |||||||
| Infiltration, mononuclear cell, focal, minimal to slight | - | - | 1/9 | - | - | - | |
| Intestine, small | |||||||
| Duodenum | - | - | - | - | - | - | |
| Jejunum | - | - | - | - | - | - | |
| Ileum | - | - | - | - | - | - | |
| Intestine, large | |||||||
| Caecum | - | - | - | - | - | - | |
| Colon | - | - | - | - | - | - | |
| Rectum | - | - | - | - | - | - | |
| Kidney | |||||||
| Cyst, tubule, focal, slight to moderate | 2/9 | - | - | - | - | - | |
| Liver | - | - | - | - | - | - | |
| Lung | |||||||
| Granuloma, foreign body, focal, slight | 1/9 | - | - | - | - | - | |
| Lymph node | |||||||
| Cervical | - | - | - | - | - | - | |
| Mesenteric | - | - | - | - | - | - | |
| Mammary gland | N | N | N | - | - | - | |
| Optic nerve | - | - | - | - | - | - | |
| Ovary | N | N | N | - | - | - | |
| Oviduct | N | N | N | - | - | - | |
| Pancreas | |||||||
| Fibrosis, islet, focal, slight | - | - | 1/9 | - | - | - | |
| Pituitary | - | - | - | - | - | - | |
| Parathyroid gland | - | - | - | - | - | - | |
| Prostate gland | N | N | N | ||||
| Infiltration, mononuclear cell, focal, minimal to moderate | 4/9 | 1/10 | 2/9 | ||||
| Salivary gland | |||||||
| Mandibular lobe | - | - | - | - | - | - | |
| Sublingual lobe | - | - | - | - | - | - | |
| Sciatic nerve | - | - | - | - | - | - | |
| Seminal vesicle | - | - | - | N | N | N | |
| Skeletal muscle | - | - | - | - | - | - | |
| Skin | - | - | - | - | - | - | |
| Spinal cord | |||||||
| Cervical | - | - | - | - | - | - | |
| Lumbar | - | - | - | - | - | - | |
| Thoracic | - | - | - | - | - | - | |
| Spleen | |||||||
| Fibrosis, serosa, focal, minimal | - | 1/10 | - | - | 1/10 | - | |
| Stomach | - | - | - | - | - | - | |
| Testes | - | - | - | - | - | - | |
| Thymus | - | - | - | - | - | - | |
| Thyroid gland | - | - | - | - | - | - | |
| Tongue | - | - | - | - | - | - | |
| Trachea | - | - | - | - | - | - | |
| Urinary bladder | - | - | - | - | - | - | |
| Uterus | N | N | N | - | - | - | |
| Vagina | N | N | N | - | - | - | |
- No effect. N: no tissue available. a Degree of lesions was graded from one to five depending on severity: 1 = minimal (<1%); 2 = slight (1–25%); 3 = moderate (26–50%); 4 = moderate/severe (51–75%); 5 = severe/high (76–100%). b Incidence: Affected rats/Total examined rats (n = 9–10).