Table 7.
Genetic features of previously published cases of ovarian mesonephric-like adenocarcinoma.
| Author | No. of Cases | KRAS Mutation | Other Recurrent Mutation | Recurrent Chromosomal Gain | Recurrent Chromosomal Loss |
|---|---|---|---|---|---|
| McFarland et al. [4]; Mirkovic et al. [5] | 5 | p.G12D (4/5); NA (1/5) | PIK3CA | 1q | 1p |
| Pors et al. [6] | 1 | NA | NA | NA | NA |
| Chapel et al. [7] | 1 | – | NRAS, BCOR | 1q, 4, 7, 13, 18p, 21 | 1p, 11, 18q, 19, 22, X |
| McCluggage et al. [8] | 5 | p.G12D (1/5); NA (4/5) | – | NA | NA |
| Pors et al. [9] | 25 | NA | NA | NA | NA |
| Dundr et al. [10] | 1 | p.G12C | PIK3CA, CHEK2 | – | – |
| Seay et al. [11] | 1 | – | – | – | – |
| Chen et al. [12] | 1 | NA | NA | NA | NA |
| da Silva et al. [13] | 15 | p.G12D (5/15); p.G12V (8/15); –(2/15) | PIK3CA, SPOP, NRAS, SETD8, CTNNB1, CREBBP, NOTCH3, ARID1A, FBXW7, FANCA, AKT1, ASXL1, RAD54L | 1q, 2, 6, 7, 8, 9, 10, 12, 16, 17, 20, 21, X | 1p, 4, 6, 15, 18, 22, X |
| Deolet et al. [14] | 4 | p.G12A (2/4); p.G12V (1/4); –(1/4) | PIK3CA, PTEN amplification, 12p isochromosome | 1q, 12, 17, 21 | – |
| Kim et al. [37] | 1 | p.G12V | – | – | – |
| Total [4,5,6,7,8,9,10,11,12,13,14,37] | 60 | p.G12D (10/28); p.G12V (10/28); p.G12A (2/28); p.G12C (1/28); –(5/28) |
Abbreviations: –, absent. Numbers enclosed in parenthesis in each cell indicate the number of positive cases per total cases reported in each article.