Table 1.
Inhibition of VEGF-induced VEGFR-2 phosphorylation and IC50 values of HT metabolites and indolic compounds.
| Compounds | Concentrations | Inhibition (%) | IC50 |
|---|---|---|---|
| DOPAL | 50 µM | 5 ± 7 | 119 µM |
| 100 µM | 46 ± 8 | (95.49–148.1) | |
| MOPAL | 100 µM | NI | ND |
| MOPET | 100 µM | NI | ND |
| IPy | 0.1 mM | 4 ± 10 | 1.037 mM |
| 1 mM | 56 ± 0.7 | (0.9061–1.171) | |
| IPA | 0.1 mM | NI | ND |
| 1 mM | NI | ||
| ILA | 0.1 mM | NI | ND |
| 1 mM | NI | ||
| IBA | 0.1 mM | NI | ND |
| 1 mM | NI |
Inhibition percentages of VEGF-induced VEGFR-2 activation are expressed as the mean ± SD (n = 3). The 95% confident intervals are shown in brackets. NI: non-inhibition. ND (not determined). DOPAL (3,4-dihydroxyphenylacetaldehyde); MOPAL (3-methoxy-4- hydroxyphenylacetaldehyde); MOPET (4-hydroxy-3-methoxyphenylethanol); IPy (indole pyruvic acid); IPA (indole propionic acid); indole lactic acid (ILA); IBA (indole butyric acid).