Table 2.
The effects of COL and BHA on the pro-inflammatory cytokines in rats with MSU-induced acute gout.
| NC | MC | COL | 10BHA | 50BHA | |
|---|---|---|---|---|---|
| IL-1α (pg/mL) | 79.4 ± 5.4 | 72.2 ± 7.0 | 74.3 ± 12.6 | 71.5 ± 11.2 | 77.4 ± 13.0 |
| IL-1β (pg/mL) | 19.6 ± 0.5 | 19.9 ± 0.5 | 19.1 ± 1.2 | 19.6 ± 1.6 | 18.8 ± 0.8* |
| IL-6 (pg/mL) | 71.1 ± 4.7 | 74.2 ± 6.2 | 74.7 ± 7.9 | 78.5 ± 5.6 | 75.0 ± 5.3 |
| IL-8 (pg/mL) | 232 ± 10.7 | 231.8 ± 8.6 | 222.7 ± 11.5 | 213.8 ± 11.4* | 216.6 ± 11.6* |
| IL-10 (pg/mL) | 11.8 ± 0.6 | 11.0 ± 0.8# | 11.5 ± 0.7 | 12.0 ± 0.9* | 11.6 ± 1.1 |
| IL-16 (pg/mL) | 397.9 ± 31.1 | 405.7 ± 20.5 | 416.7 ± 16.1 | 399.3 ± 14.8 | 401.2 ± 25.1 |
| IP-10 (pg/mL) | 143.8 ± 7.7 | 158.4 ± 23.4 | 153.5 ± 20.3 | 154.3 ± 18.0 | 150.5 ± 7.5 |
| MCP-1 (pg/mL) | 320.2 ± 16.0 | 345.8 ± 24.2# | 311.5 ± 20.8* | 321.2 ± 20.5* | 292.0 ± 27.8** |
| MIP-1α (pg/mL) | 289.8 ± 25.1 | 289.2 ± 20.3 | 294.6 ± 21.5 | 282.8 ± 23.6 | 283.9 ± 12.7 |
| IFN-γ (pg/mL) | 99.6 ± 26.0 | 112.8 ± 21.6 | 88.2 ± 35.0 | 107.4 ± 7.6 | 75.4 ± 31.7* |
| TNF-α (pg/mL) | 154.6 ± 13.4 | 156.2 ± 13.0 | 154.8 ± 8.5 | 155.9 ± 11.4 | 152.7 ± 12.1 |
| TNF-β (pg/mL) | 121.4 ± 28.2 | 127.7 ± 22.8 | 124.8 ± 10.5 | 139.1 ± 25.7 | 129.0 ± 21.9 |
| NF-κB (pg/mL) | 358.1 ± 97.0 | 501.3 ± 102.9 | 494.6 ± 132.2 | 589.8 ± 104.8 | 513.0 ± 74.1 |
| 6-Keto-PGF1α (pg/mL) | 214.5 ± 17.5 | 251.3 ± 21.7# | 266.3 ± 12.7 | 257 ± 20.8 | 262.0 ± 10.8 |
| PGE2 (pg/mL) | 195 ± 10.5 | 199.5 ± 8.6 | 207.7 ± 10.0 | 209.7 ± 17.3 | 193.2 ± 12.7 |
Data are expressed as mean ± S.D. (n = 10) and analyzed via a one-way ANOVA test followed by post-hoc Dunn’s multiple comparison tests.
#
p < 0.05 versus control rats.
*p < 0.05 and **p < 0.01 versus model rats.