Table 2.
Correlation between CYP17A1 genetic variants and PCOS with infertility.
| Gene Name | SNP/STR Allele | Study Design | Country | Ethnicity | SS; Case/Control |
Genotype-Methods | Diagnostic Criteria | Clinical Characteristics | Risk Association | Ref |
|---|---|---|---|---|---|---|---|---|---|---|
| CYP17A1 | rs743572 | Case–control study | Chile | Caucasian | 66/93 | PCR -RFLP | NIH/NICHD | hormonal and clinical evidence of PCOS | CYP17A1 is associated with metabolic pathway and obesity in women with PCOS | [65] |
| CYP17A1 | rs743572 | Case–control study | India | Asian | 100/100 | PCR-sequencing | Rotterdam | Anovulation | CYP17A1 was associated with hyperandrogenaemia | [46] |
| CYP17A1 | rs743572 | Case–control study | Iraq | Asian | 84/65 | PCR | - | Anovulation | Positive correlation | [85] |
| CYP17A1 | rs743572 | Case–control study | Iraq | Asian | 61/30 | PCR-RFLP | Rotterdam | PCOS criteria | There is a correlation between the –34 T > C allele and increasing HDL | [67] |
| CYP17A1 | rs743572 | Case–control study | India | Asian | 250/250 | PCR-RFLP | Rotterdam | Anovulation | CYP17A1 34 T > C occurrence had a significant relation with PCOS patients | [68] |
| CYP17A1 | rs743572 | Case–control study | Iran | Asian | 50/109 | PCR-RFLP | Rotterdam | PCOS criteria | Polymorphism in CYP17A1 is associated with the risk of PCOS | [70] |
| CYP17A1 | rs743572 | Case–control study | Pakistan | Asian | 204/100 | PCR-RFLP | Rotterdam | PCOS criteria | rs743572 is correlated with the occurrence of PCOS | [71] |
| CYP17A1 | rs743572 | Case–control study | India | Asian | 394/306 | PCR-RFLP | Rotterdam | Hyperandrogenism | Confirmation of the role of SNP in hyperandrogenism with increasing androgen | [72] |
| CYP17A1 | rs1004467, rs17115149, rs12413409 | Case–control study | China | Asian | 440/1320 | PCR-Genotype | - | Type two diabetes Mellitus | CYP17A1 might be considered as a risk factor to T2DM | [73] |
| CYP17A1 | rs743572 | Cross-sectional study | Thailand | Asian | 210 | PCR-RFLP | Rotterdam | PCOS criteria | There was no significant association between –34 T > C and insulin resistance | [74] |
| CYP17A1 | rs743572 | Case–control study | Turkey | Asian | 44/50 | PCR-RFLP | Rotterdam | PCOS criteria | There was no association among case and control groups in allele –34 T > C | [75] |
| CYP17A1 | rs743572 | Case–control study | America | Caucasian | 259/161 | PCR | NIH/NICHD | PCOS criteria | There was no association with the development of PCOS and CYP17A1 C/T | [76] |
NIH/NICHD: National Institutes of Health/National Institute of Child Health and Human Development; Rotterdam: Rotterdam PCOS Consensus SS: Sample Size.