Table 3.

Inflammatory factors connected with gynecological cancers.

Inflammatory Factors	Function	Association
Cyclooxygenase-2 (COX-2)	promotion of angiogenesis in adenomyosis	upregulated expression in endometrial, ovarian, and cervical cancer [35,36]
Tumor necrosis- alfa (TNF alfa)	promote production of ROS	high level in endometriosis and ovarian cancer [37]
Toll-like receptors (TLRs)—intracellular signaling components	cell surface sensors initiate proliferation and modulate immune cells—connected with chemoresistance	well described in endometriosis and ovarian cancer [38]
Tumor associated macrophages (TAMS)	promote angiogenesis, tumorigenesis, matrix remodeling, inhibits adaptive immunity	infiltrated ovarian tumor [39]
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-KB proteins)	active in tumor cells, mediate metastasis	involved in development of endometriosis and ovarian cancer [40]
Macrophage migration inhibitory factor (MIF protein)	regulator of immune and inflammatory response	found in active ectopic endometrial implants [41]