Table 2.

Reporting of adverse outcomes.

Study	Adverse Outcomes Reported	Intervention	Adverse Events
Collin and Crawley [39]	Yes	CBT and GET	Overall change in health: 20.1% felt worse at 1-year and 30.6% at 5-year follow-up
Huibers et al. [31]	Yes	CBT by GPs	None
Koolhaas et al. [37]	Yes	CBT	38% negatively affected by CBT
O’Dowd et al. [35]	No	Group CBT with Graded Activity	Not reported
Prins et al. [36]	No	CBT vs. guided support	Not reported
Ridsdale et al. [32]	No	CBT vs. counseling	Not reported
Stevelink et al. [41]	No	CBT vs. GET vs. APT vs. CBT and GET	Not reported
Stordeur et al. [40]	No	CBT and GET	Not reported
Van Berkel et al. [38]	Yes	GET	Increase in tiredness: 13.7% (3 months) and 11.5% (12 months)
White et al. [33]	Yes	CBT vs. GET vs. APT	SAE: 1% APT, 2% CBT, 1% GET and 1% SMC

SAE: serious adverse reactions to trial treatments: “adverse events were considered serious (by White et al. [33]) when they involved death, hospital admission, increased severe and persistent disability, self-harm, were life-threatening, or required an intervention to prevent one of these”.