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Schematic representation of the regulation of BCKDC. BCAAs undergo a transamination reaction by BCAAT. The resulting α-ketoacids are then oxidatively decarboxylated by BCKDH. The overall activity of BCKDH is regulated by phosphorylation/dephosphorylation by BCKDK and DCKDP, respectively. On its turn, BDKDK is negatively regulated by the α-ketoacids, leading to an increase in the activation of BCKDH (dephosphorylated state).
