Table 1.
Composition of butenafine bilosomes with vesicle size (Y1) and entrapment efficiency (Y2).
| Formulation Code | Independent Constraints | Dependent Constraints | |||
|---|---|---|---|---|---|
| Lipid (%) |
Surfactant (mg) | Bile Salt (mg) | Vesicle Size (nm) |
Entrapment Efficiency (%) |
|
| A | B | C | Y1 | Y2 | |
| F1 | 1.5 | 30 | 20 | 181.5 ± 4.5 | 67.79 ± 1.5 |
| F2 | 4.5 | 30 | 20 | 310.1 ± 7.4 | 85.99 ± 1.8 |
| F3 | 1.5 | 60 | 20 | 144.4 ± 4.8 | 76.88 ± 1.4 |
| F4 | 4.5 | 60 | 20 | 222.8 ± 5.2 | 91.29 ± 2.1 |
| F5 | 1.5 | 45 | 15 | 180.8 ± 3.5 | 69.87 ± 1.3 |
| F6 | 4.5 | 45 | 15 | 262.7 ± 6.2 | 87.56 ± 1.8 |
| F7 | 1.5 | 45 | 25 | 168.9 ± 4.1 | 72.12 ± 1.4 |
| F8 | 4.5 | 45 | 25 | 276.3 ± 6.3 | 86.99 ± 1.7 |
| F9 | 3 | 30 | 15 | 268.2 ± 5.9 | 77.38 ± 1.4 |
| F10 | 3 | 60 | 15 | 208.2 ± 4.2 | 80.99 ± 1.6 |
| F11 | 3 | 30 | 25 | 258.8 ± 5.7 | 75.46 ± 1.4 |
| F12 | 3 | 60 | 25 | 195.3 ± 4.5 | 86.50 ± 1.7 |
| F13 * | 3 | 45 | 20 | 209.6 ± 4.7 | 80.23 ± 2.7 |
| F14 * | 3 | 45 | 20 | 208.1 ± 4.4 | 80.98 ± 2.1 |
| F15 * | 3 | 45 | 20 | 209.3 ± 3.5 | 80.12 ± 1.4 |
| F16 * | 3 | 45 | 20 | 209.9 ± 4.8 | 80.21 ± 1.9 |
| F17 * | 3 | 45 | 20 | 207.9 ± 5.1 | 80.56 ± 1.3 |
* Center point (common composition); values are expressed as mean ± SD, n = 3.