Table 1.
Repair factors in Saccharomyces. cerevisiae, functions and orthologs in Schizosaccharomyces. pombe and humans.
| S. cerevisiae | S. pombe | Human | Complex | Function |
|---|---|---|---|---|
| Yku70 | Pku70 | KU70 | KU (DNA-PK) | NHEJ repair factor |
| Yku80 | Pku80 | KU80 | ||
| - | - | DNA-PKcs | ||
| Lif1 | Xrc4 | XRCC4 | XRCC4–XLF–Ligase IV | |
| Nej1 | Xlf1 | NHEJ1 (XLF) | ||
| Dnl4 | Lig4 | LIG4 (Ligase IV) |
||
| Mre11 | Mre11 | MRE11 | MRX (MRN) | NHEJ/HDR factor |
| Rad50 | Rad50 | RAD50 | ||
| Xrs2 | Nbs1 | NBS1 | ||
| Sae2 | Ctp1 | CTIP | - | HDR factor |
| Dna2 | Dna2 | DNA2 | Dna2/Sgs1 (BLM) | |
| Sgs1 | Rqh1 | BLM | ||
| Exo1 | Exo1 | EXO1 | - | |
| Rad51 | Rad51 | RAD51 | - | |
| Rad52 | Rad52 | RAD52 | - | |
| Rad1 | Rad16 | ERCC4 | Rad1–Rad10 (ERCC1–XPF) | |
| Rad10 | Swi10 | ERCC1 | ||
| Rad9 | Crb2 | TP53BP1 (53BP1) |
- | DNA damage signaling |
| Tel1 | Tel1 | ATM | - | |
| Mec1 | Rad3 | ATR | - | |
| Chk1 | Chk1 | CHEK1 | - |