Table 2.
Cohesin subunits in S. cerevisiae, functions and orthologs in S. pombe and humans.
| S. cerevisiae | S. pombe | Human | Complex | Function |
|---|---|---|---|---|
| Smc1 | Psm1 | SMC1A/B | Cohesin | Genome organization Sister chromatid cohesion |
| Smc3 | Psm3 | SMC3 | ||
| Scc1 | Rad21 | SCC1 | ||
| Scc3 | Psc3 | STAG1/2 | ||
| Scc2 | Mis4 | NIPBLA/B | Scc2/4 (NIPBL–Mau2) |
Cohesin loading partner |
| Scc4 | Ssl3 | Mau2 | ||
| Pds5 | Pds5 | PDS5 | - | Cohesin regulator |
| Wpl1 | Wpl1 | WAPL | ||
| Eco1 | Eso1 | ESCO1/2 | ||
| Esp1 | Cut1 | ESPL1 | - | Cohesin separase |
| Smc5 | Smc5 | SMC5 | SMC5/6 | DNA/chromatin processing |
| Smc6 | Smc6 | SMC6 | ||
| Mms21 | Nse2 | NSE2 | Ubiquitin ligase |