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. 2022 Jan 24;13(2):208. doi: 10.3390/genes13020208

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Network representation of lncRNAs and miRNAs gene targets for prostate cell senescence. Only genes related to Cell Cycle and Cell Proliferation are presented. Gene Targets PDGFRB, PDGFRA, CCNE2, E2F2, EGFR, ZEB1 belonging to the Prostate Cancer KEGG pathway are highlighted (gold arrow) as are CCNB1, CCNB2, FOXM1, CCNA2, CDK1, CCNE2, CDC25A, E2F2, CDKN2A, MAPK13, RBL1 (green arrow) from the Cellular Senescence pathway. The lncRNAs MYBL, SERHL and SNHG5 are not depicted as they do not have any gene targets belonging to Cell Cycle and/or Cell Proliferation. Blue indicates down-regulated and red up-regulated in senescent cells relative to non-senescent cells. Genes are presented as rectangles, miRNAs as triangles, and lncRNAs as octagons.