Figure 5.

Prostate Cancer KEEG pathway genes being perturbed and regulated by ncRNAs due Cell Senescence. The transcription factor ZEB1 is the target of a large number of ncRNAs. The DE RNA threshold in limma was log 2 Fold Change ≥ |1| and adjusted p-value (FDR) < 0.01. The Prostate Cancer KEGG pathway depiction and impact analysis were generated using iPathwayGuide (Advaita). Blue indicates down-regulated and red up-regulated in senescent cells relative to non-senescent cells. Genes are presented as rectangles, miRNAs as triangles, and lncRNAs as octagons.