Fig. 2.

CD4⁺ T cells promote bacterial burden during S. aureus bloodstream infection. In vivo T cell depletion in DR4-B6 mice was performed with monoclonal antibodies to deplete CD4⁺ (clone GK1.5) and/or CD8⁺ (clone YTS169.4) cells prior to i.v. infection with S. aureus COL. (A and B) In vivo liver bacterial burdens and pathology (A) and kidney bacterial burdens (B) were assessed 96 hpi. Each data point represents an individual mouse, and the bar indicates the geometric mean for CFUs/organ and the median for lesions/organ. Significant differences were determined using the Kruskal–Wallis test with the uncorrected Dunn’s test for multiple comparisons (*P < 0.05, **P < 0.01). ns, not significant.