Table 1.
Baseline characteristics and treatment outcomes of vaccinated vs. unvaccinated women.
| Unvaccinated (N = 200) | Vaccinated (N = 200) | P value | |
|---|---|---|---|
| Mean age (y) | 36.11 (35.49–36.73) | 36.04 (35.41–36.67) | .92 |
| Mean partner age (y) | 37.38 (36.48–38.27) | 37.51 (36.38–38.64) | .54 |
| Smoking (%) | 27.0 (15.2) | 23.0 (13.3) | .61 |
| Previous retrievals | 1.73 (1.44–2.01) | 1.83 (1.49–2.16) | .78 |
| Previous transfers | 1.82 (1.46–2.17) | 1.78 (1.43–2.13) | .48 |
| BMI | 24.36 (23.58–25.15) | 24.48 (23.68–25.27) | .87 |
| Infertility cause (%) | |||
| Male factor | 34.0 (18.8) | 35.0 (19.6) | .15 |
| Fertility preservation | 26.0 (14.4) | 14.0 (7.8) | |
| Mechanical | 14.0 (7.7) | 12.0 (6.7) | |
| Unexplained infertility | 42.0 (23.2) | 35.0 (19.6) | |
| Age-related infertility | 49.0 (27.1) | 55.0 (30.7) | |
| Other | 16.0 (8.8) | 28.0 (15.6) | |
| G (%) | |||
| 0 | 84.0 (51.2) | 77.0 (48.4) | .26 |
| 1 | 46.0 (28.0) | 37.0 (23.3) | |
| 2+ | 34.0 (20.7) | 45.0 (28.3) | |
| P (%) | .21 | ||
| 0 | 105.0 (62.1) | 93.0 (58.1) | |
| 1 | 48.0 (28.4) | 43.0 (26.9) | |
| 2+ | 16.0 (9.5) | 24.0 (15.0) | |
| Days from vaccination to retrieval | |||
| Range | - | 30.63 (28.81–32.45) 14.00–68.00 |
|
| Protocol (%) | |||
| MNC | 8.0 (4.0) | 4.0 (2) | .17 |
| Antagonist | 160.0 (80.4) | 172.0 (87.3) | |
| Long luteal | 14.0 (7.0) | 14.0 (7.1) | |
| Short | 7.0 (3.5) | 4.0 (2.0) | |
| Combined | 10.0 (5.0) | 3.0 (1.5) | |
| Ovulation triggering (%) | |||
| Dual | 83.0 (42.6) | 98.0 (52.4) | .15 |
| hCG | 51.0 (26.2) | 42.0 (22.5) | |
| GnRH agonist | 61.0 (31.3) | 47.0 (25.1) | |
| Stimulation days | 10.25 (9.42–11.09) | 9.90 (9.32–10.47) | .62 |
| Total gonadotropin dose (IU) | 2,780.14 (2,589.71–2,970.57) | 2,938.04 (2,754.47–3,121.62) | .14 |
| E2 on the day of ovulation triggering (pmol/L) | 8,070.20 (7,046.00–9,094.40) | 7,388.28 (6,223.16–8,553.40) | .24 |
| Endometrial thickness(mm) | 9.72 (9.42–10.02) | 9.60 (9.29–9.92) | .58 |
| Oocytes retrieved | 10.72 (9.53–11.91) | 10.63 (9.82–11.43) | .93 |
| Fertilization method (%) | |||
| ICSI | 99.0 (55.0) | 106.0 (54.6) | 0.94 |
| IVF | 22.0 (12.2) | 26.0 (13.4) | |
| ICSI/IVF | 59.0 (32.8) | 62.0 (32.0) | |
| MII oocytes/oocytes retrieved (%) in cycles with ICSI | 79.56% (75.07–84.04) | 83.82% (79.62–88.01) | 0.17 |
Note: Data are presented as mean and (95% confidence interval) or counts and (percentage). Mechanical factor: tubal and uterine. Age-related infertility: age of >39 years as a primary infertility indication. Combined protocol = agonist administered for 2–3 days and then replaced by an antagonist. BMI = body mass index; G = gravidity; GnRH = gonadotropin-releasing hormone; hCG = human chorionic gonadotropin; ICSI = intracytoplasmic sperm injection; IVF = in vitro fertilization; MNC = modified natural cycle; P = parity; short protocol = agonist (flare-up protocol).