Table 3.
Clinical outcomes of vaccinated vs. unvaccinated patients in embryo transfer cycles.
| Unvaccinated (N=133) | Vaccinated (N=128) | P value | |
|---|---|---|---|
| Days from vaccination to retrieval | — | 30.38 (28.05, 32.71) | — |
| Range | 14.00–68.00 | ||
| Protocol (%) | |||
| MNC | 7.0(5.3) | 4.0 (3.2) | .93 |
| Antagonist | 109.0 (82.6) | 107.0 (84.9) | |
| Long luteal | 10.0 (7.6) | 10.0 (7.7) | |
| Short | 5.0 (3.8) | 4.0 (3.2) | |
| Combined | 1.0 (0.8) | 1.0 (0.8) | |
| Ovulation triggering (%) | |||
| Dual | 70.0 (54.3) | 76.0 (63.3) | .31 |
| hCG | 42.0 (32.6) | 33.0 (27.5) | |
| GnRH agonist | 17.0 (13.2) | 11.0 (9.2) | |
| Stimulation days | 9.59 (9.05, 10.12) | 9.73 (8.94, 10.52) | .83 |
| Total Gonadotropins dose | 2,634.90 (2,406.74, 2,863.06) | 2,980.45 (2,749.12, 3,211.77) | .01 |
| E2 on the day of ovulation triggering pmol/L | 6,199.54 (5,358.01, 7,041.07) | 5,896.69 (5,113.34, 6,680.04) | .70 |
| Endometrial thickness (mm) | 9.80 (9.41, 10.20) | 9.67 (9.28, 10.06) | 0.72 |
| Oocytes retrieved | 8.32 (7.38, 9.27) | 8.47 (7.52, 9.42) | 0.78 |
| Fertilization method (%) | |||
| ICSI | 64.0 (48.5) | 65.0 (51.2) | .85 |
| IVF | 19.0 (14.4) | 19.0 (15.0) | |
| ICSI/IVF | 49.0 (37.1) | 43.0 (33.9) | |
| MII oocytes/oocytes retrieved (%) - ICSI | 80.07 (74.09–86.04) | 84.63 (79.62–89.65) | .35 |
| Fertilization rate (pronuclei/total oocytes) | 61.98 (57.37–66.60) | 64.81 (60.69–68.93) | .51 |
| Frozen embryos per cycle | |||
| Total | 1.22 (0.91–1.53) | 1.53 (1.16–1.91) | .42 |
| Day 2/3 | 1.07 (0.74–1.41) | 1.43 (0.91–1.95) | .51 |
| Day 5 | 1.07 (0.74–1.40) | 1.41 (1.08–1.74) | .11 |
| Day 6 | 0.45 (0.14–0.75) | 0.48 (0.15–0.82) | .75 |
| Embryos transferred per cycle (%) | |||
| 1 | 73.0 (54.9) | 70.0 (54.7) | .96 |
| 2 | 54.0 (40.6) | 53.0 (41.4) | |
| 3 | 6.0 (4.5) | 5.0 (3.9) | |
| Day of transfer/total transfers (%) | |||
| Day 2 | 31.0 (25.4) | 16.0 (13.7) | .07 |
| Day 3 | 70.0 (56.9) | 76.0 (65.0) | |
| Day 5 | 22.0 (17.9) | 25.0 (21.4) | |
| Top transferred embryo grade (grade/total cycles) (%) | |||
| A | 77.0 (57.9) | 71.0 (55.5) | .89 |
| B | 39.0 (29.3) | 41.0 (32.0) | |
| C | 17.0 (12.8) | 16.0 (12.5) | |
| Clinical pregnancy rate (%) | 44.0 (33.1) | 42.0 (32.8) | .96 |
| Chemical pregnancy rate (%) | 13.0 (9.8) | 6.0 (4.7) | .11 |
Note: Data are presented as mean (95% confidence interval) or counts (percentage). MNC- modified natural cycle. Combined protocol = agonist administered for 2–3 days and then replaced by an antagonist. E2 = estradiol; GnRH = gonadotropin-releasing hormone; hCG = human chorionic gonadotropin; ICSI = intracytoplasmic sperm injection; IVF = in vitro fertilization; MII = metaphase II; MNC = modified natural cycle; short protocol = agonist administered from day 1 of menstruation.