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. 2021 Sep 28;26(12):7403–7416. doi: 10.1038/s41380-021-01304-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Free-choice alcohol consumption reversed the advantageous low-depression phenotype in female mice with reduced NSM activity (fro) in the novelty supressed feeding (NSF) test, but not in (b) the forced swim test (FST). Alcohol drinking eliminated the advantageous low anxiety phenotype of female fro mice in (c) the light–dark box test (LDB), (d) in the elevated plus maze test (EPM), and in (e) the open field test (OF) (n = 6–8 per group). Data are expressed as means + s.e.m. (*P < 0.05; **P < 0.01 vs. wild type (WT). f Fro mice show an enlarged volume of the dorsal hippocampus (DH) measured by magnet resonance imaging. Voluntary alcohol drinking reduced DH size in fro mice to WT levels mice. g–k There was no significant effect of reduced NSM activity or voluntary alcohol consumption on the size of other brain areas (n = 7–8 per group). Data are expressed as means + s.e.m. (***P < 0.001). l Superoxide dismutase (SOD) in the DH was significantly reduced in fro mice after water drinking. This effect was reversed after voluntary alcohol consumption (n = 7–8 per group). m, n There was no effect of NSM or alcohol on catalase activity or lipid peroxidation in the DH. All results show mean + SEM (*P < 0.05; **P < 0.01).