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. 2021 Sep 1;26(12):7355–7362. doi: 10.1038/s41380-021-01268-x

Fig. 1. NDEV levels of proteins involved in mitochondrial dynamics and other maintenance functions.

Fig. 1

Each point represents the value for one study participant after CD81 normalization. Statistical significance of non-responder baseline (NR-Bsl) and responder baseline (R-Bsl) abnormalities were calculated relative to control values by an unpaired t test and of changes after treatment relative to respective baseline values before treatment (NR-Tr vs. NR-Bsl and R-Tr vs. R-Bsl) by a paired t test; for both comparisons NS not significant; +, p < 0.05; *, p < 0.01; **, p < 0.001. The mean ± S.E.M. (p value) of control subjects (Ctl), baseline of nonresponsive participants (NR-Bsl), nonresponsive participants after treatment (NR-Tr), baseline of responsive participants (R-Bsl) and responsive participants after treatment (R-Tr), respectively, were 825 ± 85 pg/ml, 1058 ± 105 pg/ml (NS), 1171 ± 107 pg/ml (NS), 1151 ± 72 pg/ml (p = 0.0091) and 876 ± 46 pg/ml (p = 0.0157) for CD81 (A); 1458 ± 135 pg/ml, 1255 ± 117 pg/ml (NS), 1426 ± 149 pg/ml (NS), 1357 ± 92 pg/ml (NS) and 1848 ± 152 pg/ml (0.0039) for TFAM (B); 2623 ± 266 pg/ml, 1120 ± 89 pg/ml (<0.0001), 950 ± 129 pg/ml (NS), 1452 ± 117 pg/ml (0.0008) and 2572 ± 234 pg/ml (0.0002) for MFN2 (C); 1415 ± 125 pg/ml, 473 ± 31 pg/ml (<0.0001), 438 ± 30 pg/ml (NS), 424 ± 32 pg/ml (<0.0001) and 651 ± 65 pg/ml (0.0019) for CYPD (D); 1676 ± 97 pg/ml, 758 ± 188 pg/ml (0.0004), 440 ± 44 pg/ml (NS), 523 ± 60 pg/ml (<0.0001) and 1797 ± 283 pg/ml (0.0008) for SNPH (E); 17,105 ± 1684 pg/ml, 9659 ± 1008 pg/ml (0.0013), 6269 ± 745 pg/ml (0.0473), 4915 ± 504 pg/ml (<0.0001) and 10,248 ± 1144 pg/ml (0.0017) for MY06 (F); and 2275 ± 221 pg/ml, 1212 ± 169 pg/ml (0.0012), 796 ± 103 pg/ml (0.0412), 860 ± 114 pg/ml (<0.0001) and 2197 ± 248 pg/ml (0.0004) for LETM-1 (G). Mean ± S.E.M. of levels of the same mitochondrial proteins in NDEV of previously reported sets (n = 10) of controls and participants with a first episode of psychosis [16], respectively, were 632 ± 18.2 pg/ml and 628 ± 16.6 pg/ml (NS) for TFAM; 1953 ± 395 pg/ml and 347 ± 138 pg/ml (0.0012) for MFN2; 1456 ± 133 pg/ml and 227 ± 33.3 pg/ml (<0.0001) for CYPD; 2188 ± 259 pg/ml and 4008 ± 371 pg/ml (0.0007) for SNPH; 9599 ± 1098 pg/ml and 11240 ± 1758 pg/ml (NS) for MY06; and 2322 ± 251 pg/ml and 485 ± 52.4 pg/ml (<0.0001) for LETM-1.