Table 1.
Demographics and clinical characteristics of study participants.
| MDD, responder (n = 10) | MDD, non-responder (n = 10) | Healthy control (n = 10) | |||
|---|---|---|---|---|---|
| Age at diagnosis, years (mean ± SD) | 25.3 ± 15.3 | 18.4 ± 7.0 | N/A | ||
| Study age, years (mean ± SD) | 39.0 ± 9.4 | 41.3 ± 11.6 | 37.5 ± 10.5 | ||
| Sex, female/male | 6/4 | 6/4 | 5/5 | ||
| Days of current depressive episode (mean ± SD) | 3179 ± 3089 | 5957 ± 4314 | N/A | ||
| Depression rating scale | HDRS 17 | HDRS 25 | HDRS 17 | HDRS 25 | N/A |
| HDRS at baseline (mean ± SD) | 18.0 ± 3.5 | 26.3 ± 3.3 | 19.9 ± 2.9 | 29.8 ± 5.3 | ND |
| HDRS after treatment for 8 weeks (mean ± SD) | 5.7 ± 4.0 | 7.8 ± 4.9 | 16.9 ± 3.4 | 23.6 ± 6.3 | ND |
HDRS is the Hamilton Depression Rating Scale; 17-variable version is the left-hand set and 25-variable version is the right-hand set. There are no significant differences between study groups for age, sex or baseline pre-treatment HDRS. Post-treatment HDRS values after eight weeks of treatment are significantly lower for responders than non-responders. ND Not done, N/A Not applicable