Table 3.
Comparison of alterations in NDEV levels of mitochondrial proteins in untreated first episode of psychosis (FP) and in untreated baseline for major depressive disorder (MDD).
| Class of mitochondrial analytes | FP | MDD NR-Bsl/R-Bsl |
|---|---|---|
| 1. Dynamics and maintenance functions | ||
| TFAM | ND | ND/ND |
| MFN2 | ↓82 | ↓57/45 |
| CYPD | ↓ 84 | ↓67/70 |
| SNPH | ↑ 183 | ↓55/69 |
| MY06 | ND | ↓ 44/71 |
| LETM1 | ↓ 79 | ↓47/62 |
| 2. Energy generation | ||
| Complex I-6 | ↓66 | ↓53/80 |
| Complex III-10 | ↓55 | ↓68/77 |
| NMNAT 2 | ↓ 34 | ↓65/69 |
| SARM 1 | ND | ↑ 443/409 |
| 3. Metabolic regulation and cellular survival | ||
| Humanin | ↓88 | ND/ ↓62 |
| MOTS-c | ↓88 | ↓84/83 |
| 4. Mitochondrial biogenesis | ||
| PGC1α | ND | ND/ND |
| NRF2 | ↓ 63 | ↓45/64 |
Each value represents the mean percentage change from controls for FP patients and for baseline levels of MDD groups non-responsive (NR-Bsl) and responsive (R-Bsl) to therapy. ND is no significant difference between mentally ill participants and controls. Up arrows and down arrows indicate increases and decreases of mitochondrial protein levels in mental illness, respectively.