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. 2021 Aug 6;26(12):7661–7670. doi: 10.1038/s41380-021-01244-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A PCA of CSF basic and flow cytometry parameters: Each patient is depicted as a multidimensional data point. The group means are illustrated as larger circles and the confidence intervals are shown by ellipses around each group mean point. B Heatmap of CSF basic and flow cytometry parameters: The mean of each parameter was calculated, scaled, centered, and clustered hierarchically. C Box plots of selected individual CSF flow cytometry parameters: Lower quartile, median and upper quartile are shown by boxes. Whiskers depict 1.5 times the interquartile range of the box and outliers are illustrated by dots. The Kruskal Wallis tests with post hoc two-sided Dunn test and Benjamini-Hochberg’s adjusted p values were used to calculate the significance. (BBBD: blood-brain-barrier dysfunction; cMono: classical monocytes; CSF: cerebrospinal fluid; F2x: patients with psychotic disorder; Ig: immunoglobulin; IIH: intracranial hypertension; iMono: intermediate monocytes; NK: natural killer cells; ncMono: non-classical monocytes; NMDARE: anti-NMDA-receptor encephalitis; ocb: oligoclonal band; PC: principal component; PCA: principal component analysis; RRMS: Relapsing-Remitting Multiple Sclerosis).