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. 2021 Oct 18;26(12):7167–7187. doi: 10.1038/s41380-021-01291-y

Fig. 11. Exercise attenuated surgery-induced GDNF decrease, immune and inflammatory responses and dendritic arborization impairment in old mice.

Fig. 11

Nineteen-month old male mice with or without exercise for 4 weeks were subjected to left carotid artery exposure (surgery) under isoflurane anesthesia. A GDNF expression. B C3 expression. C Representative Iba-1 and C3ar immunostaining images. D Quantitative data of Iba-1 and C3ar immunostaining. E IL-1β and IL-6 expression. F Representative GFAP and BrdU immunostaining images. G Quantitative data of GFAP and BrdU immunostaining. H Representative Golgi staining. I Quantitative data of intersections among dendritic branches and spine density. Results in panels A, D and E are median ± interquartile range with presentation of value of individual mouse and results in panels B, G and I are mean ± S.D. with presentation of value of individual mouse (n = 10 for panels A, = 12 for panel B, = 6 for panels D and G, = 8 for panels E and I). Exe exercise, Sur surgery.