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. 2021 Oct 18;26(12):7167–7187. doi: 10.1038/s41380-021-01291-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Nine-week old male mice with or without exercise for 4 weeks were subjected to left carotid artery exposure (surgery) under isoflurane anesthesia. In another experiment, 9-week old mice were treated with antibiotics to eliminate their native gut microbiota and then transplanted with feces from exercise mice (ET) or control mice (CT). Presentation of α diversity is in (panels A, C, E and G). Presentation of β diversity is in (panels B, D, F and H). n = 16 for (panels A and B, and = 8 for other panels). C-S: control mouse samples harvested before surgery, E-ES: exercise mouse samples harvested before surgery, S: surgery mouse samples harvested just before surgery, SP3: surgery mouse samples harvested on post-surgery day 3, SP7: surgery mouse samples harvested on post-surgery day 7, ES: exercise mouse samples harvested just before surgery, ESP3: exercise mouse samples harvested on post-surgery day 3, ESP7: exercise mouse samples harvested on post-surgery day 7, CT: samples harvested from mice transplanted with feces from control mice, ET: samples harvested from mice transplanted with feces from exercise mice.