. 2021 Dec 4;46(3):637–645. doi: 10.1038/s41366-021-00975-3

Table 2.

Association between cord blood leptin and adiponectin and neonatal adiposity.

	Birth weight (N = 650)	Triceps skinfold (N = 626)	Subscapular skinfold (N = 625)	Fat Mass (PEAPOD) (N = 197)	Fat Mass (predicted) (N = 625)	sSAT (N = 213)	dSAT (N = 213)	IAT (N = 213)
	β (95% CI)	β (95% CI)	β (95% CI)	β (95% CI)	β (95% CI)	β (95% CI)	β (95% CI)	β (95% CI)
Cord blood Leptin	0.212 (0.259, 0.266)	0.267 (0.186, 0.349)	0.319 (0.238, 0.400)	0.378 (0.237, 0.519)	0.281(0.218, 0.343)	0.258 (0.142, 0.374)	0.386 (0.254, 0.517)	0.250 (0.118, 0.383)
	P < 0.001^a	P < 0.001^a	P < 0.001^a	P < 0.001^a	P < 0.001^a	P < 0.001^b	P < 0.001^b	P = 0.001^b
Cord blood Adiponectin	0.110 (0.059, 0.162)	0.158 (0.080, 0.235)	0.179 (0.102, 0.256)	0.136 (0.014, 0.257)	0.154 (0.094, 0.215)	0.185 (0.096, 0.274)	0.173 (0.067, 0.278)	0.092 (−0.011, 0.195)
	P < 0.001^a	P < 0.001^a	P < 0.001^a	P = 0.033^a	P < 0.001^a	P < 0.001^b	P = 0.002^b	P = 0.081^b

Standardized scores of cord blood leptin and adiponectin as exposures. Standardized scores of birth weight, triceps skinfold, subscapular skinfold, fat mass,

sSAT, dSAT, and IAT as outcomes.

Coefficients (β) with 95% confidence intervals (95% CI) are change in independent variables per standardized score value change in cord blood leptin or adiponectin. P values were determined with the use of multivariable regression models and corrected for multiple analyses using Benjamini–Hockberg method. Significant p-values < 0.05 are indicated in bold.

sSAT Abdominal superficial subcutaneous adipose tissue, dSAT Abdominal deep subcutaneous adipose tissue, IAT Abdominal internal adipose tissue.

^aModels are adjusted for ethnicity, pre-pregnancy BMI, gestational diabetes mellitus (GDM) status, gestational age at delivery, and child’s sex and birth length.

^bModels are adjusted for ethnicity, pre-pregnancy BMI, GDM status, gestational age at delivery, and child’s sex, birth length and age on MRI day.