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. 2021 Sep 6;26(12):7270–7279. doi: 10.1038/s41380-021-01283-y

Fig. 4. Selective stimulation of septal OXTr neuron projections to HDB induced anxiety.

Fig. 4

a Schematic illustration of experimental design. A vector carrying Cre-dependent hM3Dq or mCherry was bilaterally targeted to the lateral septum, and a guide cannula was implanted for intra-HDB injections in Oxtr-Cre mice. b Representative tracks of the open field test (OFT) in the septum of OXTr hM3Dq (right, n = 8)- and mCherry (left, n = 6)-transduced mice. c Time spent in the center of the open field. d Percent center distance traveled in the OFT. e The number of center entries in the OFT. f Representative traces of the EPM recorded in the septal OXTr hM3Dq (right, n = 8)- and mCherry (left, n = 7)-transduced mice. g Time spent in the open arms of the EPM. h The number of entries in the open arms. Two-tailed unpaired Student’s t-tests were used to analyze all panels. Mean ± SEM; *p < 0.05; ns not significant.