Table 3.
Group-specific protein alterations via pairwise analysis of TMT-LC/MS data.
| Enviromimetic drug/risk factor treatment group | ||||||
|---|---|---|---|---|---|---|
| WIN 55,212-2 | IL17A | Cortisol | Nicotine | Ethanol | Endomorphin | |
| ↑ TXNRD1 | ↑ GPR89A | ↑ NDUFB9 | ↑ ROBO1 | ↑ ELOF1 | ↑ MTHFD1L | ↑ EFNB3 |
| ↑ UBA6 | ↑ SUB1 | ↑ PBDC1 | ↑ FSD1L | ↑ MPP2 | ↑ MAP4K4 | ↑ NEDD8 |
| ↑ AT2C1 | ↑ DR1 | ↑ RBM28 | ↑ ELAVL2 | ↑ PHF14 | ↑ MYO18A | ↑ TBC1D9B |
| ↑ TRMT10A | ↑ GATD1 | ↑ FLYWCH2 | ↑ CAMK2G | ↑ NELFB | ↑ TSEN34 | ↑ SLC27A4 |
| ↑ TSPAN3 | ↓ NEBL | ↑ ROCK2 | ↑ CNTN2 | ↑ PAK1 | ↑ GATAD2B | ↑ EDC4 |
| ↑ YIPF4 | ↓ SUPT4H1 | ↑ NME7 | ↑ CHCHD3 | ↑ PPP4R2 | ↑ EIPR1 | ↑ LARP4 |
| ↑ TIMM17B | ↓ DIS3 | ↑ RIF1 | ↑ NDRG3 | ↑ NRCAM | ↑ PPIL3 | ↑ TAOK1 |
| ↑ CST3 | ↑ SLC16A2 | ↑ GGA3 | ↑ CLASP2 | ↑ AARSD1 | ↑ BPHL | |
| ↑ GSPT1 | ↑ ABCB6 | ↑ DCAKD | ↑ DCTN6 | ↑ MRPL39 | ↑ SBF2 | |
| ↑ CPE | ↑ ZNF579 | ↑ PRKRA | ↑ CTNND2 | ↑ ARVCF | ↑ ZC3H7A | |
| ↑ ARF4 | ↑ PDLIM3 | ↑ GNAI3 | ↑ CFL1 | ↑ NEFM | ↑ PTGR2 | |
| ↑ MMUT | ↑ GCC2 | ↑ RBM25 | ↑ HS1BP3 | ↑ THY1 | ↑ UBA3 | |
| ↑ SHMT2 | ↑ NDUFA2 | ↑ EIF2B2 | ↑ YLPM1 | ↑ TSG101 | ↑ FAM172A | |
| ↑ NAA10 | ↓ ARMC9 | ↑ MCAM | ↑ MACF1 | ↑ PRKAG1 | ↑ UBTD2 | |
| ↑ TUFM | ↓ INTS9 | ↑ NOVA1 | ↑ MPRIP | ↑ LRRC57 | ↑ RTF1 | |
| ↑ SLC25A3 | ↓ VIRMA | ↑ EIF5 | ↑ DOHH | ↑ EPS15L1 | ↑ CLCC1 | |
| ↑ CPSF1 | ↓ NUP210 | ↑ CDK16 | ↑ DAZAP1 | ↑ AGRN | ↑ TRIM2 | |
| ↑ TRIP12 | ↑ INA | ↑ DPYSL4 | ↑ PSMD14 | ↑ EGLN1 | ||
| ↑ SART3 | ↑ CIAPIN1 | ↑ SPTBN2 | ↑ SDCBP | ↑ FAM234A | ||
| ↑ WDR43 | ↑ DHX57 | ↑ KIF5C | ↑ TRAFD1 | ↑ WDR13 | ||
| ↑ DHCR24 | ↑ UBE2R2 | ↑ RTN3 | ↑ UQCRQ | ↑ DPH5 | ||
| ↑ PCID2 | ↑ TRMT10C | ↑ CTPS1 | ↑ PLXNB2 | ↑ MYG1 | ||
| ↑ METTL3 | ↑ NIT1 | ↑ CTNNA2 | ↑ ZW10 | ↑ HMG20A | ||
| ↑ NDUFAF2 | ↑ TTC5 | ↑ ABCD3 | ↑ NIPSNAP2 | ↑ PHPT1 | ||
| ↑ RDH11 | ↑ TNPO1 | ↑ CARS1 | ↑ PDCD6 | ↑ SH3BP4 | ||
| ↑ GBF1 | ↑ RSF1 | ↑ PEX3 | ↑ GCAT | ↑ UQCR10 | ||
| ↑ EXOC4 | ↑ GAN | ↑ TBL3 | ↑ ATRN | ↑ VPS28 | ||
| ↑ GTPBP4 | ↑ ACTR10 | ↑ DBN1 | ↑ TTC4 | ↑ VPS4A | ||
| ↑ NIF3L1 | ↑ SACS | ↑ TBCEL | ↑ GNAI2 | ↑ PACSIN2 | ||
| ↑ GHITM | ↑ COPG2 | ↑ CADM2 | ↑ EIF2S1 | ↑ PSMD13 | ||
| ↑ EXD2 | ↑ CNOT11 | ↑ AMER2 | ↑ NEFL | ↑ RABGAP1 | ||
| ↑ BPNT2 | ↑ MAGED1 | ↑ GDAP1 | ↑ GALT | ↓ SELENOH | ||
| ↑ YARS2 | ↓ TTC28 | ↑ DTD1 | ↑ CNP | ↓ EIF1AD | ||
| ↑ RRP15 | ↓ MTAP | ↑ CLIP2 | ↑ G6PD | ↓ RPL28 | ||
| ↑ AUP1 | ↓ DOCK4 | ↑ UBQLN2 | ↑ FDPS | ↓ DVL2 | ||
| ↓ DOCK1 | ↓ SYNCRIP | ↑ DCTN4 | ↑ EIF2AK2 | ↓ RPL19 | ||
| ↓ ACSS3 | ↓ PDIA6 | ↑ NOVA2 | ↑ RAB6A | ↓ RPL4 | ||
| ↓ MEX3A | ↓ PDCD4 | ↓ RPS9 | ↑ ATP2B4 | ↓ ARL1 | ||
| ↓ ENSA | ↓ DIPK2A | ↓ SENP3 | ↑ OTX1 | ↓ RPL5 | ||
| ↓ FAM171A2 | ↓ NAA50 | ↑ CRAT | ↓ RPL34 | |||
| ↓ PDCD10 | ↓ RPL15 | ↑ CRK | ↓ NUP107 | |||
| ↓ ATOX1 | ↓ PLOD2 | ↑ CRKL | ↓ RPL23A | |||
| ↓ SORBS2 | ↓ MEIS2 | ↑ BRCC3 | ↓ PPP2CA | |||
| ↓ STX8 | ↓ ATP1A1 | ↑ DHPS | ↓ HNRNPD | |||
| ↓ TLK2 | ↓ S100A6 | ↑ IST1 | ↓ NUFIP2 | |||
| ↓ MIF | ↓ FBL | ↑ CACNA2D1 | ↓ BTF3L4 | |||
| ↓ PPT1 | ↓ FKBP2 | ↑ RAB5B | ↓ API5 | |||
| ↓ CNN3 | ↓ NMT1 | ↑ COPS2 | ↓ LSM6 | |||
| ↓ HMGN3 | ↓ TSFM | ↑ NCALD | ↓ LAS1L | |||
| ↓ PKN2 | ↓ TPMT | ↑ SNRPF | ||||
| ↓ LGALSL | ↓ CASP7 | ↑ RAC1 | ||||
| ↓ ZC3H13 | ↓ NUTF2 | ↑ VAC14 | ||||
| ↓ MTDH | ↓ RPL11 | ↑ TRAF2 | ||||
| ↓ LSM2 | ↓ DDI2 | ↑ IFIT5 | ||||
| ↓ ISOC1 | ↑ HNRNPD | |||||
| ↓ SFXN2 | ↑ UBE4A | |||||
| ↑ ELAVL3 | ||||||
| ↑ LAGE3 | ||||||
| ↑ CRYM | ||||||