Table 5.
Statistics for metabolites altered across human-derived organoid groups.
| Enviromimetic Drug/Risk factor treatment group | ||||||
|---|---|---|---|---|---|---|
| WIN | IL17a | CORT | Nicotine | Ethanol | Endomorphin | |
| Log2FC, p Value | Log2FC, p Value | Log2FC, p Value | Log2FC, p Value | Log2FC, p Value | Log2FC, p Value | |
| 3-Phosphoglyceric Acid | −2.72,0.03 | −2.23, 0.04 | ||||
| Acetylcysteine | −0.74,0.04 | |||||
| Allantoin | −0.66,0.02 | −0.65,0.01 | ||||
| Creatinine | −0.36,0.01 | −0.22, 0.03 | −0.27,0.01 | −0.23, 0.02 | ||
| D-Ribose 5-Phosphate | −1,06, 0.003 | |||||
| Guanosine Monophosphate | −0.61, 0.005 | |||||
| Guanosine Triphosphate | Inf,0.04 | Inf,0.04 | Inf,0.04 | Inf,0.04 | Inf,0.04 | |
| Inosine | −1.19, 0.008 | |||||
| L-Leucine | −0.26,0.02 | −0.17, 0.02 | −0.20, 0.01 | |||
| L-Methionine | −0.45,0.003 | −0.39, 0.02 | −0.33,0.01 | −0.38, 0.007 | −0.27,0.03 | |
| L-Phenylalanine | −0.30, 0.003 | −0.32,0.007 | −0.27, 0.02 | −0.25, 0.005 | −0.26, 0.002 | −0.21,0.04 |
| L-Tyrosine | −0.27, 0.013 | −0.30,0.005 | −0.22, 0.02 | −0.22,0.03 | −0.19, 0.0004 | |
| L-Valine | −0.31, 0.03 | −0.19,0.04 | −0.13,0.04 | −0.15, 0.02 | ||
| N-Acetylglutamine | −0.85, 0.03 | |||||
| N-Acetylornithine | −0.51,0.03 | −0.56, 0.01 | −0.47, 0.04 | |||
| Pyruvic Acid | −1.68,0.009 | |||||
| S-Adenosylhomocysteine | −1.39, 0.04 | −1.61,0.01 | ||||
| Succinic Acid | −0.43, 0.03 | |||||
∞/Inf = infinite LC/MS intensity range due to non-detection in the vehicle control group.