Table 4.
Anti-oligoSia/polySia antibodies.
| Group | Clone | Organism | Immunoglobulin type | Immunogen | Type of sialic acid recognized | DP specificity |
|---|---|---|---|---|---|---|
| I) Anti-polySia | H.46 | Horse | poly, IgM | Neisseria meningitidis GpB | Neu5Ac | DP≥8 |
| 735 | Mouse | Mono, IgG2a | Neisseria meningitidis GpB | Neu5Ac | DP≥11 | |
| II) Anti-oligoSia + anti-polySia antibody | 12E3 | Mouse | Mono, IgM | Embryonic rat forebrain | Neu5Ac | DP≥5 |
| 5A5 | Mouse | Mono, IgM | Membrane from embryonic rat spinal cord | Neu5Ac | DP≥3 | |
| 2-2B | Mouse | Mono, IgM | Neisseria meningitidis GpB | Neu5Ac | DP≥4 | |
| OL.28 | Mouse | Mono, IgM | Oligodendrocyte from newborn rat | Neu5Ac | DP≥4 | |
| 2-4B | Mouse | Mono, IgM | Oligo/polyNeu5Gc-PE | Neu5Gc | DP≥2 | |
| Kdn8kdn | Mouse | Mono, IgM | KDN-gp | KDN | DP≥2 | |
| III) Anti-oligoSia antibody | S2-566 | Mouse | Mono, IgM | Human GD3 | Neu5Ac | DP=2 |
| 1E6 | Mouse | Mono, IgM | (Neu5Ac)2-bearing artificial glycopolymer | Neu5Ac | DP=2 | |
| AC1 | Mouse | Mono, IgG3 | (Neu5Gc)GD1c | Neu5Gc | DP=2–4 | |
| Other | 12F8 | Rat | Mono, IgM | Mouse membrane fraction | Unknown | Unknown |
Poly, polyclonal; mono, monoclonal.