TABLE 3.
Univariate and multivariate Cox regression analysis for overall survival.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age (≤60 vs. >60 years) | 1.880 (1.034–3.419) | 0.039 a | ||
| Gender (male vs. female) | 0.823 (0.458–1.478) | 0.514 | ||
| Smoking (yes vs. no) | 1.137 (0.547–2.362) | 0.731 | ||
| Size (>3 vs. ≤3 cm) | 0.599 (0.310–1.158) | 0.128 | ||
| Stage (I, II, III vs. IV) | 6.648 (2.653–16.657) | 0.000 a | 4.064 (1.325–12.465) | 0.014 a |
| Lymph nodes involved (yes vs. no) | 0.426 (0.236–0.769) | 0.005 a | 0.380 (0.155–0.932) | 0.034 a |
| Neural invasion (yes vs. no) | 0.958 (0.422–2.074) | 0.913 | ||
| Vascular invasion (yes vs. no) | 0.545 (0.252–1.181) | 0.124 | ||
| ATF6 (high vs. low) | 0.378 (0.206–0.696) | 0.002 a | 0.229 (0.099–0.530) | 0.001 a |
| XBP1 (high vs. low) | 1.080 (0.603–1.936) | 0.795 | ||
| CHOP (high vs. low) | 0.981 (0.549–1.753) | 0.948 | ||
| EMC6 (high vs. low) | 2.082 (1.105–3.924) | 0.023 a | 2.956 (1.290–6.772) | 0.010 a |
| APAF1 (high vs. low) | 2.117 (1.092–4.103) | 0.026 a | 2.369 (1.069–5.249) | 0.034 a |
Note. HR, hazard ratio.
95% CI, 95% confidence interval.
a
Statistically significant results (p < 0.05).