TABLE 4.
Univariate and multivariate Cox regression analysis for disease-specific survival.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age (≤60 vs. >60 years) | 2.029 (1.077–3.823) | 0.029 a | ||
| Gender (male vs. female) | 0.865 (0.467–1.602) | 0.645 | ||
| Smoking (yes vs. no) | 1.068 (0.508–2.245) | 0.861 | ||
| Size (>3 vs. ≤3 cm) | 0.592 (0.296–1.184) | 0.138 | ||
| Stage (I, II, III vs. IV) | 7.494 (2.865–19.604) | 0.000 a | 4.073 (1.284–12.922) | 0.017 a |
| Lymph nodes involved (yes vs. no) | 0.396 (0.213–0.739) | 0.004 a | 0.396 (0.159–0.983) | 0.046 a |
| Neural invasion (yes vs. no) | 1.016 (0.445–2.319) | 0.969 | ||
| Vascular invasion (yes vs. no) | 0.546 (0.239–1.246) | 0.150 | ||
| ATF6 (high vs. low) | 0.327 (0.170–0.631) | 0.001 a | 0.183 (0.077–0.438) | 0.000 a |
| XBP1 (high vs. low) | 1.073 (0.579–1.988) | 0.824 | ||
| CHOP (high vs. low) | 1.072 (0.579–1.983) | 0.826 | ||
| EMC6 (high vs. low) | 2.028 (1.044–3.937) | 0.037 a | 3.275 (1.255–8.550) | 0.015 a |
| APAF1 (high vs. low) | 2.397 (1.170–4.909) | 0.017 a | 2.887 (1.112–7.496) | 0.029 a |
Note. HR, hazard ratio.
95% CI, 95% confidence interval.
a
Statistically significant results (p < 0.05).